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Table 1 Baseline clinical and haematology data in children with moderate and severe malarial anaemia

From: Ultrasonographic assessment of splenic volume at presentation and after anti-malarial therapy in children with malarial anaemia

  Moderate malarial anaemia Severe malarial anaemia P-value
(n = 10) (n = 15)
Age (months) 74 (58–87) 36 (32–49) 0.001
Male sex (%) 50 40 0.47
Axillary temperature (°C) 37.1 (36.3-38.6) 37.6 (36.6-38.0) 0.75
Pulse rate (beats/min) 97 (80–120) 128 (109–135) 0.003
Respiratory rate (breaths/min) 28 (23–33) 28 (28–39) 0.14
Blantyre Coma Score ≤4 (%) 0 20 0.20
Palpable spleen size (cm) 5.5 (3.7-7.0) 4 (2.0-7.9) 0.50
Hackett’s grade 2.5 (2–3) 3.0 (1.0-4.0) 0.93
Splenic volume (cm3) 84 (49–102) 54 (36–149)a 0.66
Total White cell count (109/L) 6.5 (3.1-9.1) 9.5 (6.5-18.8) 0.032
Lymphocytes (%) 46 (32–56) 40 (21–57) 0.42
Monocytes (%) 11 (7–18) 9.6 (6–12) 0.32
Granulocytes (%) 46 (32–53) 51 (32–72) 0.30
Total platelet count (109/L) 108 (50–221) 126 (43–211) <0.001
Haemoglobin (g/L) 77 (67–87) 46 (39–49) <0.001
Red blood cell count (1012/L) 2.7 (2.3-3.6) 2.2 (1.3-4.4) 0.42
Haematocrit (%) 22 18–26) 16 (10–25) 0.13
Mean cell volume (fL) 66 (62–77) 63 (55–83) 0.56
Mean cell haemoglobin (pg) 20 (19–24) 22 (19–27) 0.25
Mean cell haemoglobin concentration (g/L) 310 (284–324) 339 (308–380) 0.024
Red cell distribution width 17.5 (14.2-21.0) 19.1 (15.3-30.1) 0.42
P. falciparum density (/μL) 5776 (235–33,569) 600 (190–3388) 0.37
  1. aTwo children in the SMA group did not have a valid splenic volume measurement
  2. Data are medians (interquartile range) or percentages