Table 1 Baseline clinical and haematology data in children with moderate and severe malarial anaemia
| Â | Moderate malarial anaemia | Severe malarial anaemia | P-value |
|---|---|---|---|
(n = 10) | (n = 15) | ||
Age (months) | 74 (58–87) | 36 (32–49) | 0.001 |
Male sex (%) | 50 | 40 | 0.47 |
Axillary temperature (°C) | 37.1 (36.3-38.6) | 37.6 (36.6-38.0) | 0.75 |
Pulse rate (beats/min) | 97 (80–120) | 128 (109–135) | 0.003 |
Respiratory rate (breaths/min) | 28 (23–33) | 28 (28–39) | 0.14 |
Blantyre Coma Score ≤4 (%) | 0 | 20 | 0.20 |
Palpable spleen size (cm) | 5.5 (3.7-7.0) | 4 (2.0-7.9) | 0.50 |
Hackett’s grade | 2.5 (2–3) | 3.0 (1.0-4.0) | 0.93 |
Splenic volume (cm3) | 84 (49–102) | 54 (36–149)a | 0.66 |
Total White cell count (109/L) | 6.5 (3.1-9.1) | 9.5 (6.5-18.8) | 0.032 |
Lymphocytes (%) | 46 (32–56) | 40 (21–57) | 0.42 |
Monocytes (%) | 11 (7–18) | 9.6 (6–12) | 0.32 |
Granulocytes (%) | 46 (32–53) | 51 (32–72) | 0.30 |
Total platelet count (109/L) | 108 (50–221) | 126 (43–211) | <0.001 |
Haemoglobin (g/L) | 77 (67–87) | 46 (39–49) | <0.001 |
Red blood cell count (1012/L) | 2.7 (2.3-3.6) | 2.2 (1.3-4.4) | 0.42 |
Haematocrit (%) | 22 18–26) | 16 (10–25) | 0.13 |
Mean cell volume (fL) | 66 (62–77) | 63 (55–83) | 0.56 |
Mean cell haemoglobin (pg) | 20 (19–24) | 22 (19–27) | 0.25 |
Mean cell haemoglobin concentration (g/L) | 310 (284–324) | 339 (308–380) | 0.024 |
Red cell distribution width | 17.5 (14.2-21.0) | 19.1 (15.3-30.1) | 0.42 |
P. falciparum density (/μL) | 5776 (235–33,569) | 600 (190–3388) | 0.37 |