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Table 1 Affinities (KD values) of purified humAb10.1, humAb10.2 and humAb10.3 as determined by SPR spectroscopy using the recombinant MSP-based fusion protein multi-EGF

From: Isolation, production and characterization of fully human monoclonal antibodies directed to Plasmodium falciparum MSP10

Antibody

Expression system

Ka (M−1 s−1)

Kd (s−1)

KD (M)

humAb10.1 (H5F6:κ5E8)

Nicotiana benthamiana

4.43 × 103

4.11 × 10−3

9.27 × 10−7

humAb10.2 (H5F6:κ5F8)

Nicotiana benthamiana

5.31 × 105

2.90 × 10−3

5.46 × 10−9

LCL 5F6

4.46 × 105

2.95 × 10−3

6.62 × 10−9

humAb10.3 (H5E6:κ5E8)

Nicotiana benthamiana

2.32 × 105

1.15 × 10−3

5.39 × 10−9

LCL 5E8

3.99 × 105

3.06 × 10−4

8.04 × 10−10