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Table 3 Impact of Vernonia amygdalina leaf extracts on the development of early sporogonic stages in vitro

From: Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds

Test agents

Experimenta

Mean ESS counts (95% CI)b

Percentage inhibition of ESS (95% CI)

Ver-EtOH

1

53 (46–60)

81.3 (79.1–83.7)

2

11 (3–19)

96.2 (93.4–99.1)

3

18 (15–20)

87.5 (85.8–89,14)

4

45 (41–50)

88 (86.7–89.4)

Sol-EtOH

1

285 (239–332)

 

2

283 (261–306)

 

3

141 (120–163)

 

4

378 (310–446)

 

Ver-H2O

5

51 (42–60)

14 (5–23.1)

6

23 (14–32)

38.7 (14.2–63.3)

Sol-H2O

5

59 (51–68)

 

6

37 (32–42)

 
  1. Ver-EtOH and Ver-H2O were tested at 50 µg/mL.
  2. Data are presented as mean early sporogonic stages (ESS) counts calculated from triplicate wells and percentages of ESS inhibition referred to solvent controls. Both parameters are presented with 95% confidence intervals (95% CI).
  3. Ver-EtOH ethanolic V. amygdalina leaf extract, Ver-H 2 O aqueous V. amygdalina leaf extract, Sol-EtOH (dimethyl sulfoxide at 0.2%) and Sol-H2O (phosphate buffered saline) are solvent controls for the ethanolic and aqueous extract, respectively.
  4. aEach number represents one experiment conducted with gametocytaemic blood from a different mouse.
  5. bMean ESS counts are rounded to the nearest whole numbers.
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Malaria Journal

ISSN: 1475-2875

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