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Table 6 Transmission blocking activity of ethylacetate fractions from Vernonia amygdalina leaves on Plasmodium falciparum isolates

From: Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds

Blood sample Gametocytes per µL blood Treatment % Prevalence of infected mosquitoes (infected/total examined) Oocyst densitya (95% CI)
1 160 Solvent control 42.2 (19/45) 4.2 (2.7–6.6)
Fraction-11 5.1 (2/39)* 2.4 (1.6–3.6)
Fraction-13 8.3 (3/36)* 1.8 (0.6–5.9)
Fraction-14 26.2 (11/42) 3.5 (2.3–5.5)
2 184 Solvent control 29.6 (13/44) 3.6 (1.7–5.5)
Fraction-11 32.4 (12/37) 1.8 (0.3–3.3)
Fraction-13 6.5 (3/46)* 1.3 (0–2.8)
Fraction-14 6.7 (3/45)* 1.3 (0–2.8)
3 80 Solvent control 50 (23/46) 3.5 (2.2–5.4)
Fraction-11 0 (0/36)*
Fraction-13 0 (0/27)*
Fraction-14 7.3 (3/41)* 1
  1. Fisher’s exact test was used to compare the proportion of infected mosquitoes between control and treatment groups.
  2. aOocyst density was calculated considering infected mosquitoes only. *P < 0.05 with respect to the solvent control (dimethyl sulfoxide). Fractions were tested at 100 µg/mL.