Table 6 Transmission blocking activity of ethylacetate fractions from Vernonia amygdalina leaves on Plasmodium falciparum isolates
From: Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds
Blood sample | Gametocytes per µL blood | Treatment | % Prevalence of infected mosquitoes (infected/total examined) | Oocyst densitya (95% CI) |
|---|---|---|---|---|
1 | 160 | Solvent control | 42.2 (19/45) | 4.2 (2.7–6.6) |
Fraction-11 | 5.1 (2/39)* | 2.4 (1.6–3.6) | ||
Fraction-13 | 8.3 (3/36)* | 1.8 (0.6–5.9) | ||
Fraction-14 | 26.2 (11/42) | 3.5 (2.3–5.5) | ||
2 | 184 | Solvent control | 29.6 (13/44) | 3.6 (1.7–5.5) |
Fraction-11 | 32.4 (12/37) | 1.8 (0.3–3.3) | ||
Fraction-13 | 6.5 (3/46)* | 1.3 (0–2.8) | ||
Fraction-14 | 6.7 (3/45)* | 1.3 (0–2.8) | ||
3 | 80 | Solvent control | 50 (23/46) | 3.5 (2.2–5.4) |
Fraction-11 | 0 (0/36)* | – | ||
Fraction-13 | 0 (0/27)* | – | ||
Fraction-14 | 7.3 (3/41)* | 1 |