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Table 7 Impact of vernolide and vernodalol on the development of early sporogonic stages in vitro

From: Plasmodium transmission blocking activities of Vernonia amygdalina extracts and isolated compounds

Test compounds Experimenta Mean ESS counts (95% CI)b Percentage inhibition of ESS (95% CI)
Vernodalol 1 24 (21–26) 79.3 (77.3–81.4)
2 12 (8–16) 89.7 (86.4–92.9)
3 92 (77–107) 69.3 (64.3–74.3)
Vernolide 1 103 (90–115) 9.4 (0–20.5)
2 79 (63–95) 30.6 (16.7–44.5)
3 201 (182–220) 33 (26.6–39.3)
Solvent control (0.2% DMSO) 1 113 (93–134)  
2 114 (97–132)  
3 300 (284–317)  
  1. Compounds were tested at a concentration of 50 μM.
  2. aEach number represents one experiment conducted with gametocytaemic blood from a different mouse; ESS counts are means from sextuplicate wells.
  3. bMean ESS counts are rounded to the nearest whole numbers.