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Table 3 Number of AEs or laboratory abnormalities by grade and group in the erythrocytic phase: after initiation of treatment of malaria or day 21 until the end of follow up visits on day 90

From: Controlled human malaria infection by intramuscular and direct venous inoculation of cryopreserved Plasmodium falciparum sporozoites in malaria-naïve volunteers: effect of injection volume and dose on infectivity rates

Severity grade

Challenge group

Total

(n = 6 for each group)

Group 1

2,500 PfSPZ 10 µL × 2 IM

Group 2

2,500 PfSPZ 50 µL × 2 IM

Group 3

2,500 PfSPZ 250 µL × 2 IM

Group 4

3,200 PfSPZ 500 µL × 1 DVI

Group 5

25,000 PfSPZ 10 µL × 2 IM

Group 6

75,000 PfSPZ 10 µL × 2 IM

No subjects with P. falciparum parasitaemia

4

1

2

6

6

6

25

Grade 1

25

21

23

51

53

62

235

Grade 2

18

8

18

28

19

26

117

Grade 3

2

0

4

6

4

9

25

Total

45

29

45

85

76

97

377

  1. PfSPZ Plasmodium falciparum sporozoite, IM intramuscular injection, DVI direct venous inoculation.