Table 4 Number of volunteers with haematological and biochemical changes at 24 h after initiation of treatment for Plasmodium falciparum infection and on days 35 and 90 after injection of PfSPZ Challenge
Parameter | Normal range | Ranges of laboratory abnormalities | Number of volunteers with laboratory abnormalities among the 25 that developed malaria | |||
|---|---|---|---|---|---|---|
Screening | 24 h after first detection of parasitaemia | Day 35 after injection of PfSPZ Challenge | Day 90 after injection of PfSPZ Challenge | |||
Hb level | 120–170 g/L | <120 g/L | 1 (119 g/L) | 5 (lowest value 106 g/L) | 5 (lowest value 103 g/L) | 3 (lowest value 104 g/L) |
WBC count | 4.0–11.0 × 109 cells/L | <4.0 × 109 cells/L | 2 (lowest value 3.75 × 109 cells/L) | 16 (lowest value 2.4 × 109 cells/L) | 1 (3.6 × 109 cells/L) | 0 |
Lymphocyte count | 0.9–4.5 × 109 cells/L | <0.9 × 109 cells/L | 0 | 16 (lowest value 0.3 × 109 cells/L) | 0 | 0 |
Platelet count | 130–400 × 109 cells/L | <130 × 109 cells/L | 0 | 6 (lowest value 68 × 109 cells/L) | 0 | 0 |
ALT | 5–40 IU/L | ≥1.1 ULN | 0 | 6 (highest value 159 IU/L) | 0 | 0 |
AST | 5−40 IU/L | ≥1.1 ULN | 1 (58 IU/L) | 6 (highest value 125 IU/L) | 0 | 1 (44 IU/L) |
LDH | <450 IU/L | ≥450 IU/L | 2 (highest value 515 IU/L) | 9 (highest value 652 IU/L) | 1 (466 IU/L) | 0 |
Creatinine | 0.3–1.3 mg/dL | Any abnormality | 0 | 0 | 0 | 0 |