Table 6 Parasitaemia data by microscopy and qPCR and pre-patent periods by group
Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | |
|---|---|---|---|---|---|---|
2,500 PfSPZ 10 µL × 2 IM | 2,500 PfSPZ 50 µL × 2 IM | 2,500 PfSPZ 250 µL × 2 IM | 3,200 PfSPZ 500 µL × 1 DVI | 25,000 PfSPZ 10 µL × 2 IM | 75,000 PfSPZ 10 µL × 2 IM | |
N = 6 | N = 6 | N = 6 | N = 6 | N = 6 | N = 6 | |
Number of volunteers who became thick blood smear positive (TBS+) | 4 | 1 | 2 | 6 | 6 | 6 |
Listing of times to TBS+ (days) | 14.0, 15.0, 15.0, 12.0 | 14.0 | 16.0, 14.0 | 11.0, 10.4, 12.3, 10.9, 11.9, 12.2 | 12.4, 12.4, 13.3, 12.4, 11.1, 12.0 | 11.8, 11.0, 11.0, 11.0, 12.0, 12.0 |
Geometric mean time to TBS+ (days) | 13.9 | 14.0 | 15.0 | 11.4 | 12.2 | 11.4 |
Listing of parasite density at time of TBS+ (parasites/µL blood) | 10.0, 48.0, 6.0, 5.0 | 34.0 | 10.0, 27.0 | 5.0, 1.3, 10.0, 8.0, 12.0, 14.0 | 4.0, 10.0, 5.8, 10.0, 3.8, 3.3 | 56.0, 0.8, 0.8, 6.0, 3.3, 6.6 |
Geometric mean parasite density at time of TBS+ (parasites/µL blood) | 11.0 | 34.0 | 16.4 | 6.6 | 5.5 | 4.1 |
Listing of times to qPCR+ (days) | 11.0, 11.3, 11.4, 10.0 | 9.1 | 11.0, 8.0 | 6.9, 9.1, 8.0, 8.0, 9.0, 8.9 | 10.1, 8.0 9.1, 7.0 7.0, 7.1 | 6.9, 7.0, 7.0, 7.0 7.0, 6.0 |
Geometric mean of time to qPCR+ (days) | 10.9 | 9.1 | 9.3 | 8.3 | 7.9 | 6.8 |