Therapeutic assessment of chloroquine–primaquine combined regimen in adult cohort of Plasmodium vivax malaria from a tertiary care hospital in southwestern India

Table 1 Clinical-demographic profile of study participants (N = 125) with P. vivax monoinfection from southwestern India treated with chloroquine (25 mg/kg over 3 days) followed by primaquine (0.25 mg/kg daily for 14 days)

Settings	Outpatient (N = 41)		Inpatient (N = 84)		p value^$
Variables	Mean ± SD/median (IQR)	Range	Mean ± SD/median (IQR)	Range	p value^$
Age in years	33.6 ± 13.2	18–76	35.3 ± 13.3	18–73	0.49
Duration of fever in days	3 (2, 4)	1–30	4 (3, 6)	1–60	0.14
Axillary temperature at presentation (^oC)	99.2 ± 1.0	98.6–102	100.3 ± 1.7	98.6–104	<0.001
Defervescence time in hours	8 (0, 17)	0–48	12 (4.5, 33.5)	0–148	0.001
Parasite index on day ‘0’ (parasites/µL)	1,164 (803–1,686)^a	41–11,640	1,255 (932–1,690)^a	64–21,700	0.17

Settings	Outpatient (N = 41)	Inpatient (N = 84)	p value^$
Variables	Frequency (%)	Frequency (%)	p value^$
Gender (males)	39 (95.1)	71 (84.5)	0.14
Empiric antibiotics	0	1 (1.2)	1.00
Treatment failure	0	1 (1.2)	1.00
nPCR proven mixed malaria	3 (7.3)	5 (6)	0.72

^aGeometric mean with 95% confidence interval of geometric mean.
^$p value obtained by either independent t test or Mann–Whitney U test or Chi square test as applicable, p values <0.05 are shown in italic face.

ISSN: 1475-2875