Administration of aqueous extract results in the resistance of mice to Plasmodium berghei-infection. C57BL/6 mice received 100 mg/kg of A. blazei extract or chloroquine (30 mg/kg) 3 days before infection, then infected with 105
P. berghei red blood cells (pRBCs), and treated until 7 dpi. a Parasitaemia, b survival and c clinical signs of cerebral malaria assessed by the RMCBS scale and d body weight of untreated P. berghei-infected mice and treated with chloroquine or A. blazei aqueous extract. Neurologic signs of CM appeared on days 6–12 (shaded area), with death occurring 24–48 h after onset. e Haematocrit was assessed on 5th dpi in the above groups and in mice uninfected. Parasitaemia, body weight and haematocrit (%) values are expressed as mean ± SD of 5 mice per group. #
p < 0.001, log-rank test and **p < 0.01 and ***p < 0.001, ANOVA followed Bonferroni’s test.