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Table 2 Results of logistic regression analysis investigating the effect of age, gender and HbS genotype on malaria status as determined by microscopya using combined data.

From: Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Factor Adjusted OR (95 % CI) p-value Malaria status by microscopy
Individuals positive (total = 1,966) Individuals negative (total = 7,261)
N (%) N (%)
Age (years)
 <1 1   37 (10.9) 303 (89.1)
 1–2 1.33 (0.87–2.05) 0.191 47 (17.2) 225 (82.7)
 2–5 2.65 (1.88–3.72) <0.001 311 (26.7) 854 (73.3)
 5–15 3.49 (2.53–4.86) <0.001 1,141 (25.6) 3,314 (74.4)
 15–30 1.21 (0.87–1.70) 0.263 281 (17.1) 1,365 (82.9)
 >30 0.63 (0.44–0.90) 0.010 147 (11.1) 1,177 (88.9)
Gender
 Female 1   1,044 (20.1) 4,142 (79.9)
 Male 1.09 (0.98–1.21) 0.109 922 (22.8) 3,119 (77.2)
HbS
 11 1   1,824 (21.4) 6,718 (78.6)
 12 0.75 (0.61–0.92) 0.005 136 (21.1) 508 (78.9)
 22 ND ND 0 (0) 8 (100)
  1. Data from Senegal, Mali (Pongonon), Sudan and Sri Lanka are not included as participants are either entirely microscopically malaria-positive or malaria-negative.
  2. Reference category is “negative” (n = 7261).
  3. Results significant at 0.05 level are highlighted in italics.
  4. ND: Results not shown as unable to obtain estimates for HbSS without any infected individuals.
  5. NB: CI confidence interval, OR odds ratio.
  6. aAlso adjusted for altitude, village (>20), ethnicity (>20), sample month (>20) and study; results not shown.