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Table 3 Results of linear regression analysis investigating the effect of age, gender and malaria status as determined by microscopyb on logged antibody levels to AMA1, MSP1, MSP2, NANP and IgE

From: Genetic determinants of anti-malarial acquired immunity in a large multi-centre study

Factor Anti-AMA1 levels (n = 10,137) Anti-MSP1 levels (n = 10,200) Anti-MSP2 levels (n = 10,283) Anti-NANP levels (n = 5,531)a Total IgE levels (n = 4,961)a
Beta (95 % CI) p-value Beta (95 % CI) p-value Beta (95 % CI) p-value Beta (95 % CI) p-value Beta (95 % CI) p-value
Age (years)
 <1 0   0   0   0   0  
 1–2 0.04 (−0.09 to 0.17) 0.576 −0.10 (−0.22 to 0.01) 0.083 0.16 (0.05 to 0.28) 0.006 0.30 (0.04 to 0.55) 0.023 0.09 (−0.17 to 0.35) 0.508
 2–5 0.25 (0.15 to 0.35) <0.001 0.08 (−0.01 to 0.17) 0.087 0.29 (0.20 to 0.38) <0.001 0.50 (0.30 to 0.71) <0.001 0.09 (−0.12 to 0.30) 0.398
 5–15 0.57 (0.47 to 0.67) <0.001 0.37 (0.28 to 0.45) <0.001 0.61 (0.52 to 0.69) <0.001 0.87 (0.67 to 1.07) <0.001 0.19 (−0.01 to 0.40) 0.066
 15–30 0.55 (0.46 to 0.65) <0.001 0.65 (0.57 to 0.74) <0.001 0.72 (0.63 to 0.81) <0.001 1.43 (1.23 to 1.63) <0.001 0.22 (0.02 to 0.43) 0.034
 >30 0.53 (0.43 to 0.63) <0.001 0.81 (0.72 to 0.90) <0.001 0.72 (0.63 to 0.81) <0.001 1.61 (1.40 to 1.81) <0.001 0.14 (−0.07 to 0.35) 0.179
Gender
 Female 0   0   0   0   0  
 Male −0.03 (−0.07 to 0) 0.058 −0.08 (−0.11 to −0.05) <0.001 −0.05 (−0.07 to −0.02) 0.002 −0.07 (−0.11 to −0.03) 0.004 0.12 (0.09 to 0.16) <0.001
Microscopy result  
 Negative 0   0   0   0   0  
 Positive 0.17 (0.13 to 0.22) <0.001 0.15 (0.11 to 0.19) <0.001 0.21 (0.18 to 0.25) <0.001 −0.03 (−0.08 to −0.02) 0.263 0.06 (0.01 to 0.11) 0.021
  1. Results shown as betas, which indicate the direction of effect of the clinical covariate on antibody levels. Beta < 0 indicate a decrease in antibody levels and beta > 0 indicate an increase in antibody levels. 95 % confidence intervals that do not span 0 indicate an effect that is significant at p = 0.05.
  2. NB: CI confidence interval; results significant at 0.05 level are highlighted in italics.
  3. aData not available for Tanzania (Moshi).
  4. b Also adjusted for village (>20), ethnicity (>20), sample month (>20) and study; results not shown but ANOVA p-values were <0.001 for all antibodies.