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Fig. 1 | Malaria Journal

Fig. 1

From: Inhibition by stabilization: targeting the Plasmodium falciparum aldolase–TRAP complex

Fig. 1

Schematic overview of the glideosome components and principle of enzyme inhibition and complex stabilization. a The gliding machinery is anchored between the parasite plasma membrane and the inner membrane complex (IMC). Aldolase mediates a bridging function between short actin filaments and TRAP. b Simplified model of a single aldolase sub-unit with TRAP and F16P binding sites. TRAP-binding promoters (green) occlude access to the catalytic site of aldolase.

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