Fig. 1
From: Inhibition by stabilization: targeting the Plasmodium falciparum aldolase–TRAP complex
Schematic overview of the glideosome components and principle of enzyme inhibition and complex stabilization. a The gliding machinery is anchored between the parasite plasma membrane and the inner membrane complex (IMC). Aldolase mediates a bridging function between short actin filaments and TRAP. b Simplified model of a single aldolase sub-unit with TRAP and F16P binding sites. TRAP-binding promoters (green) occlude access to the catalytic site of aldolase.