Fig. 10
From: Inhibition by stabilization: targeting the Plasmodium falciparum aldolase–TRAP complex
Delayed dissociation of TRAP bound to PfAldolase measured via SPR. Dose-dependent dissociation delay of PfTRAP-tail from PfAldolase immobilized on an SPR chip. A fixed amount of PfTRAP-tail fused via a linker to Maltose binding protein was measured in the presence of increasing concentrations of compound 24 using SPR. Indicated with dashed lines is the dissociation delay observed at concentrations greater than 500 µM of compound 24.