The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial

Table 3 Main effects of iron fortified CF-FeFum and IPT of malaria

	Effect of iron fortified complementary food		Effect of intermittent preventive treatment of malaria
	Received CF-FeFum^a	n = 250	Received IPT^a	n = 251
	No CF-FeFum^a	n = 252	IPT-placebo^a	n = 251
Adjusted^b difference of Hb concentration g/dl (95 % CI)
6 months	0.11	(−0.20 to 0.42; P = 0.49)	0.35	(0.04 to 0.66; P = 0.027)
9 months	−0.08	(−0.42 to 0.26; P = 0.65)	0.24	(−0.10 to 0.59; P = 0.16)
Adjusted^c ratios of log-transformed PF concentration (95 % CI)
6 months	1.33	(1.14 to 1.51; P = 0.001)	0.95	(0.76 to 1.13; P = 0.58)
9 months	1.36	(1.16 to 1.56; P < 0.001)	0.91	(0.70 to 1.11; P = 0.37)
Adjusted^d ratios of log-transformed CRP concentration
6 months	1.04	(0.63 to 1.45; P = 0.84)	0.77	(0.36 to 1.18; P = 0.27)
9 months	1.10	(0.65 to 1.55; P = 0.67)	0.53	(0.08 to 0.98; P = 0.039)

^aAssignment at baseline
^bAdjusted for age, Hb concentration at baseline and factorial design
^cAdjusted for age, C-reactive protein concentration, PF concentration at baseline and factorial design
^dAdjusted for age, C-reactive protein concentration at baseline and factorial design
The effects were assessed in 12- to 36-month-old Ivorian children at 6 and 9 months. The estimations are based on a 2 × 2 factorial analysis using a linear regression model taking into account random effects

ISSN: 1475-2875