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Table 1 Pfdhfr, pfdhps, pfcrt and pfmdr1 haplotypes among P. falciparum monoclonal infections

From: Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea

  Total 2006 (%) East Sepik 2006 (%) Madang 2006 (%) p value Madang 2010 (%) p value
Monoclonal infections 210 96 114   63  
pfdhfr genotype (codons 51-59-108-164)
 Wild type
  N-C-S-I 5 (2.4) 5 (5.2) 0 0.001 0 NS
 Single mutant
  N-C-N-I 3 (1.4) 3 (3.1) 0   0  
  N-R-S-I 0 0 0   1 (1.6)  
 Double mutant
  I-C-N-I 1 (0.5) 1 (1.0) 0   0  
  N-R-N-I 201 (95.7) 87 (90.6) 114 (100)   62 (98.4)  
pfdhps genotype (codons 436/437-540-581-613)
 Wild type:
  SA-K-A-A 200 (95.2) 89 (92.7) 110 (96.5) NS 43 (68.3) <0.001
 Single mutant:
  SG-K-A-A 7 (3.3) 3 (3.1) 4 (3.5)   10 (15.9)  
 Double mutant
  SG-E-A-A 2 (1.0) 2 (2.1) 0   10 (15.9)  
  SG-K-G-A 1 (0.5) 1 (1.0) 0   0  
pfcrt genotype (codons 72/73/74/75/76)
 Wild type
  CVMNK 18 (8.6) 15 (15.6) 3 (2.7) 0.001 1 (1.2) NS
 Double mutant
  SVMNT 191 (91.0) 80 (83.3) 111 (97.4)   62 (98.4)  
 Triple mutant
  CVIET 1 (0.5) 1 (1.0) 0   0  
pfmdr1 genotype (codons 86-184-1034-1042-1246)
 Wild type
  N-Y-S-N-D 10 (4.8) 6 (6.3) 4 (3.5) NS 0 NS
 Single mutant
  Y-Y-S-N-D 196 (93.3) 88 (91.7) 108 (94.7)   62 (98.4)  
 Double mutant
  N-F-S-D-D 2 (1.0) 0 2 (1.8)   0  
  Y-Y-S-D-D 1 (0.5) 1 (1.0) 0   0  
 Triple mutant
  Y-F-S-D-D 0 0 0   1 (1.2)  
 Quintuple mutant
  Y-F-C-D-Y 1 (0.5) 1 (1.0) 0   0