Skip to main content

Table 2 Pvdhfr, pvdhps and pvmdr1 haplotypes among P. vivax monoclonal infections

From: Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea

  Total 2006 (%) East Sepik 2006 (%) Madang 2006 (%) p value Madang 2010 (%) p value
Monoclonal infections 108 42 66   38  
pvdhfr genotype (codons 57/58/61-117-173)
 Wild type
  FST-S-I 38 (35.2) 22 (52.4) 16 (24.2) 0.001 1 (2.6) 0.012
 Single mutant
  FST-N-I 1 (0.9) 1 (2.4) 0   0  
 Double mutant
  FRT-N-I 4 (3.7) 1 (2.4) 3 (4.5)   1 (2.6)  
  LRT-S-I 22 (20.4) 10 (23.8) 12 (18.2)   7 (18.4)  
 Triple mutant
  LRT-T-I 2 (1.9) 1 (2.4) 1 (1.5)   3 (7.9)  
 Quadruple mutant
  LRM-T-I 41 (38.0) 7 (16.7) 34 (51.5)   26 (68.4)  
pvdhps genotype (codons 382/383-553-647)
 Wild type
  SC-A-A 3 (2.8) 0 3 (4.5) NS 4 (10.5) NS
 Single mutant
  SC-A-P 104 (96.3) 42 (100) 62 (93.9)   34 (89.5)  
 Double mutant
  SG-A-P 1 (0.9) 0 1 (1.5)   0  
pvmdr1 genotype (codon 976)
 Wild type
  Y 50 (46.3) 31 (73.8) 19 (28.8) <0.001 11 (28.9) NS
 Mutant
  F 58 (53.7) 11 (26.2) 47 (71.2)   27 (71.1)