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Table 3 Prevalence of point mutations found in dhfr/dhps genes from included studies

From: Falciparum malaria molecular drug resistance in the Democratic Republic of Congo: a systematic review

 

Authors

Year of collecting

Dhps mutations

Dhfr mutations

Quint. mutant (dhfr and dhps)

Wild

A437G

K540E

Double mutants

N51I

C59R

S108N

Triple mutants

dhps

dhfr

both

1.

Alker et al.

2002

72 %

67 %

>95 %

66 %

>95 %

43 %

1 %

2.

Cohuet et al.

2003–2004

<20 %

>50 %

0.9–12.8 %

29.4–75.6 %

1–3.9 %

3.

Swarthout et al.

2004

0.6 %

45.2 %

3.2 %

46.2 %

27.1 %

30 %

7.6 %

3 %

4

Taylor et al.

2007

14.6 %

35.1 %

5.

Mobula et al.

2008

93.1 %

9.5 %

97.9 %

80.7 %

99.1 %