Skip to main content

Table 3 Protective efficacy of DHA/PQ when stratified by PQ exposure

From: Variable piperaquine exposure significantly impacts protective efficacy of monthly dihydroartemisinin-piperaquine for the prevention of malaria in Ugandan children

Treatment arm

PQ strataa

N

Number of cases

PYAR

Incidence of malaria

Univariate

Multivariateb

PE (95 % CI)

p value

PE (95 % CI)

p value

No chemoprevention

89

723

105.9

6.83

Low

40

242

50.7

4.77

31 % (5–50 %)

0.023

31 % (6–49 %)

0.017

Monthly DHA/PQ

Medium

37

115

50.8

2.26

67 % (53–77 %)

<0.001

67 % (54–76 %)

<0.001

High

10

3

15.0

0.20

97 % (91–99 %)

<0.001

97 % (89–99 %)

<0.001

  1. DHA/PQ dihydroartemisinin/piperaquine, PYAR person years at risk, PE protective efficacy
  2. aPQ strata based on average PQ exposure score [0 to <1 (“low”), 1 to <2 (“medium”), and >2 (“high”)]
  3. bMultivariate model includes housing location, type, maternal age, and education level of primary care giver