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Table 3 Pharmacokinetic parameters of mefloquine when administered alone and in combination with LPV/r

From: Pharmacokinetic interactions between artesunate-mefloquine and ritonavir-boosted lopinavir in healthy Thai adults

Pharmacokinetic parameter

Mefloquine

p value

Alone

With LPV/r

GMR (90 % CI)

tmax (h)

33.0 (30.4, 35.5)

33.0 (30.4, 35.5)

1.04 (0.94, 1.14)

0.473

Cmax (ng/mL)

2900 (2440, 3350)

2340 (2050, 2630)

0.87 (0.72, 1.06)

0.039*

AUC0–48h (μg h/mL)

952 (711, 1192)

678 (474, 882)

0.72 (0.54, 0.97)

0.001*

AUC0-168 (μg h/L)

331 (283, 380)

208 (169, 248)

0.70 (0.55, 0.88)

0.002*

AUC0–∞ (μg h/mL)

1160 (924, 1397)

751 (471, 1031)

0.75 (0.54, 1.04)

0.007*

t1/2z (h)

344 (284, 404)

336 (267, 406)

1.14 (0.90, 1.45)

0.408

CL/F (L/h)

1.08 (0.78, 1.37)

1.67 (1.03, 2.30)

1.33 (0.96, 1.84)

0.004*

Vz/F (L/kg)

9.24 (7.67, 10.81)

12.75 (8.15, 17.35)

1.51 (1.10, 2.08)

0.010*

  1. Data are presented as median (95 % CI) and GMR (90 % CI)
  2. * Statistically significant difference (Wilcoxon Signed-Rank test)
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Malaria Journal

ISSN: 1475-2875

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