A systematic review of the efficacy of a single dose artemisinin–naphthoquine in treating uncomplicated malaria

Malaria Journal

Table 2 Review authors ‘judgment on the risk of bias of included trials

Description of domains	Author, publication year [reference no.]
Description of domains	Hombhanje et al., 2009 [19]	Rujumba et al., 2010 [20]	Kinde-Gazard et al., 2012 [21]	Tjitra et al., 2012 [22]	Udoh et al., 2014 [23]
Random sequence generation	Yes	Unclear	Yes	Yes	Yes
Allocation concealment	Open label	Unclear	Yes	Open label	Open label
Blinding of outcome assessment	Unclear	Yes	Yes	Yes	Unclear
Incomplete outcome data adequately addressed	Yes	Unclear	Yes	Yes	Yes
Free of suggestion of selective outcome reporting^a	Yes	Unclear	Yes	Yes	Yes
Addressed other sources of potential bias	Yes	Yes	Yes^b	Yes	Yes
Sample size calculation	Yes^c	No	No	Yes	Yes

‘Yes’ indicates ‘low risk of bias; ‘No’ indicates ‘high risk of bias’; ‘Unclear’ indicates ‘uncertain risk of bias’
^aIncluded all expected outcomes
^bMean parasite counts at baseline are significantly different between the two arms
^cDescribed as sufficient sample

ISSN: 1475-2875