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Table 5 HbS allelic and genotypic frequency (TA for dbSNP rs334) and severe malaria association HbS conditioned to parasitaemia levels

From: Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

Genetic testing

HP

nHP

HP/UM

nHP/UM

HP/UIF

nHP/UIF

n = 178 (%)

n = 110 (%)

P

P

P

P

OR (95 % CI)

OR (95 % CI)

OR (95 % CI)

OR (95 % CI)

Allelic (T)

1.1

6.4

1.8 × 10−7

0.13

4.9 × 10−9

0.16

  

0.11 (0.04–0.30)

0.53 (0.24–1.21)

0.10 (0.04–0.26)

0.67 (0.38–1.18)

Genotypica

1.1

1.8

1 × 10−4

0.23

1. 9 × 10−6

1. 6 × 10−2

  

0.19 (0.08–0.48)

0.55 (0.21–1.45)

0.11 (0.04–0.27)

0.42 (0.20–0.85)

  1. The numbers for HP and nHP represent only those with successful genotyping
  2. HP hyperparasitaemia, nHP non-hyperparasitaemia, UM uncomplicated malaria, UIF uninfected
  3. aPerformed with the dominant genetic model comparing A/A genotypic frequencies to T/A and T/T frequencies