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Table 5 HbS allelic and genotypic frequency (TA for dbSNP rs334) and severe malaria association HbS conditioned to parasitaemia levels

From: Quantitative trait locus analysis of parasite density reveals that HbS gene carriage protects severe malaria patients against Plasmodium falciparum hyperparasitaemia

Genetic testing HP nHP HP/UM nHP/UM HP/UIF nHP/UIF
n = 178 (%) n = 110 (%) P P P P
OR (95 % CI) OR (95 % CI) OR (95 % CI) OR (95 % CI)
Allelic (T) 1.1 6.4 1.8 × 10−7 0.13 4.9 × 10−9 0.16
   0.11 (0.04–0.30) 0.53 (0.24–1.21) 0.10 (0.04–0.26) 0.67 (0.38–1.18)
Genotypica 1.1 1.8 1 × 10−4 0.23 1. 9 × 10−6 1. 6 × 10−2
   0.19 (0.08–0.48) 0.55 (0.21–1.45) 0.11 (0.04–0.27) 0.42 (0.20–0.85)
  1. The numbers for HP and nHP represent only those with successful genotyping
  2. HP hyperparasitaemia, nHP non-hyperparasitaemia, UM uncomplicated malaria, UIF uninfected
  3. aPerformed with the dominant genetic model comparing A/A genotypic frequencies to T/A and T/T frequencies