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Table 2 Clinical data, histopathological changes and clinical complications of severe malaria cases

From: A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury

Parameter Non-PE PE p value
Clinical data and complication
 Age (years) 5–42 (20.8 ± 14.6) 3–54 (24.5 ± 13.4) 0.485
 Parasitaemia/µl on admission 412,042.72 ± 224,608.34 594,576.50 ± 822,975.64 0.480
 % PRBC sequestration 65.5 ± 40.68 74.0 ± 36.18 0.552
 Anaemia (%) 100 (11/11) 55 (11/20) 0.012
 Jaundice (%) 54.5 (6/11) 80 (16/20) 0.217
 Pneumonia (%) 45.5 (5/11) 45 (9/20) 1.000
 Acute renal failure (%) 27.3 (3/11) 30 (6/20) 1.000
 Acidosis (%) 63.6 (7/11) 15 (3/20) 0.013
 Shock (%) 9.1 (1/11) 20 (4/20) 0.631
 Systemic bleeding (%) 9.1 (1/11) 20 (4/20) 0.631
 Hypoglycaemia (%) 18.2 (2/11) 5 (1/20) 0.281
 Cerebral malaria (%) 63.6 (7/11) 70 (14/20) 1.000
Histopathological changes (median score)
 Alveolar expansion 1.46 ± 1.24 1.64 ± 0.95 0.607
 Septal congestion 1.73 ± 1.09 1.78 ± 0.68 0.848
 Malarial pigment 1.73 ± 1.09 2.00 ± 0.86 0.385
 Alveolar haemorrhage 0.93 ± 1.09 1.03 ± 1.13 0.778
 PRBCs sequestration 1.46 ± 1.12 1.42 ± 0.95 0.908
 WBC accumulation 2.20 ± 0.77 2.00 ± 0.60 0.356
 Hyaline membrane formation 0.13 ± 0.35 0.39 ± 0.73 0.037
Treatments (number/cases)
 Quinine 3/11 11/20
 Artemeter 0/11 2/20
 Quinine and artesunate 0/11 1/20
 Artesunate and artemeter 1/11 0/20
 Data were not available 7/11 6/20