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Fig. 1 | Malaria Journal

Fig. 1

From: The kdr-bearing haplotype and susceptibility to Plasmodium falciparum in Anopheles gambiae: genetic correlation and functional testing

Fig. 1

Fine structure of haplotypes in the para gene region measured as level of homozygosity. Mosquitoes were genotyped across ~15 Mb spanning the chromosome 2 centromere (long vertical grey line), first using a set of 105 SNPs (black SNP track) to detect the extent and approximate limits of the haplotype containing the para gene. Individuals were then grouped based on their genotype as defined by seven highly informative haplotype-tagging markers (blue SNP track), yielding three groups with haplotype status, HapA/HapA, HapA/HapB, HapB/HapB. Homozygosity was plotted for all individuals by genotype, depicted on the y axis as the fraction of homozygous individuals at each marker nucleotide position (for all individuals homozygous, y = 1; for all individuals heterozygous, y = 0). The region of homozygosity for the haplotype-tagging markers is indicated by a horizontal blue line, with the seven tag SNP positions marked by black stars within the horizontal blue line. The HapA allele carries the kdr mutation of the para gene

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