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Table 2 Comparison of all the tests against the reference PCR method

From: Diagnostic performance of a novel loop-mediated isothermal amplification (LAMP) assay targeting the apicoplast genome for malaria diagnosis in a field setting in sub-Saharan Africa

  PCR +ve PCR −ve Total  
LAMP +ve 120 7 127 Sn = 91.6 % (95 % CI 85.5–95.7); Sp = 96.7 % (95 % CI 93.3–98.7)
LAMP −ve 11 203 214 PPV = 94.5 % (95 % CI 89.1–97.8); NPV = 94.9 % (95 % CI 91.1–97.4)
κ = 0.91 (95 % CI 0.84-0.94)
Mx +ve 102 2 104 Sn = 77.9 % (95 % CI 70.1–84.7); Sp = 99.1 % (95 % CI 96.6–99.9)
Mx −ve 29 208 237 PPV = 98.1 % (95 % CI 93.2–99.8); NPV = 87.8 % (95 % CI 82.9–91.7)
κ = 0.80 (95 % CI 0.73-0.87)
RDT +ve 100 26 126 Sn = 76.3 % (95 % CI 68.1–83.3); Sp = 87.6 % (95 % CI 82.4–91.8)
RDT −ve 31 184 215 PPV = 79.4 % (95 % CI 71.3–86.1); NPV = 85.6 % (95 % CI 80.2–90.1)
κ = 0.64 (95 % CI 0.56-0.73)
Total 131 210 341  
  1. Sn sensitivity, Sp specificity, κ Kappa coefficient, PPV positive predictive value, NPV negative predictive value