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Table 4 Plasma concentration–time profiles of ART with or without CHR (n = 5)

From: Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

Ratio t 1/2 (h) AUC0–t [mg/(L h)] Cmax (mg/L) CLz (L/h/kg)
ART alone 3.62 ± 0.86 390.58 ± 32.46 51.58 ± 9.47 0.013 ± 0.001
ART-CHR-L (1:1) 3.89 ± 1.93 562.20 ± 101.50** 84.76 ± 19.52* 0.009 ± 0.002*
ART-CHR-M (1:2) 6.07 ± 2.04*,# 547.68 ± 76.59** 85.22 ± 29.56* 0.009 ± 0.001**
ART-CHR-H (1:4) 3.28 ± 0.77 505.21 ± 54.88** 63.16 ± 16.50 0.010 ± 0.001**
  1. Data are mean values ± SD in five rats
  2. Significantly different from ART alone: * P < 0.05, ** P < 0.01
  3. Significantly difference from ART-CHR-H: # P < 0.05