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Table 4 Plasma concentration–time profiles of ART with or without CHR (n = 5)

From: Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

Ratio

t 1/2 (h)

AUC0–t [mg/(L h)]

Cmax (mg/L)

CLz (L/h/kg)

ART alone

3.62 ± 0.86

390.58 ± 32.46

51.58 ± 9.47

0.013 ± 0.001

ART-CHR-L (1:1)

3.89 ± 1.93

562.20 ± 101.50**

84.76 ± 19.52*

0.009 ± 0.002*

ART-CHR-M (1:2)

6.07 ± 2.04*,#

547.68 ± 76.59**

85.22 ± 29.56*

0.009 ± 0.001**

ART-CHR-H (1:4)

3.28 ± 0.77

505.21 ± 54.88**

63.16 ± 16.50

0.010 ± 0.001**

  1. Data are mean values ± SD in five rats
  2. Significantly different from ART alone: * P < 0.05, ** P < 0.01
  3. Significantly difference from ART-CHR-H: # P < 0.05
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Malaria Journal

ISSN: 1475-2875

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