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Table 5 In vivo antimalaria pharmacodynamic effect of ART in combination with CHR

From: Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

Groups

Dosage (mg/kg)

Parasitemia (%, n = 10)

P value

Inhibition (%, n = 10)

placebo

ART alone

Placebo

0

22.15 ± 6.25

–

–

 

CHR-L

5

19.74 ± 13.33

0.62

–

–

CHR-M

10

17.19 ± 5.45

0.05

–

–

CHR-H

20

18.32 ± 8.86

0.25

–

–

ART alone

5

13.95 ± 7.89*

0.01

–

37.06

ART-CHR-L

5 (1:1)

9.95 ± 5.36*

2.73 × 10−5

0.07

55.10

ART-CHR-M

10 (1:2)

8.75 ± 4.25*,#

2.16 × 10−6

0.04

60.51#

ART-CHR-H

20 (1:4)

11.00 ± 4.98*

2.72 × 10−5

0.18

50.36

  1. * P values of drugs in relation to placebo: P < 0.05
  2. # P values of ART-CHR combination groups in relation to ART alone: P < 0.05