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Table 5 In vivo antimalaria pharmacodynamic effect of ART in combination with CHR

From: Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

Groups Dosage (mg/kg) Parasitemia (%, n = 10) P value Inhibition (%, n = 10)
placebo ART alone
Placebo 0 22.15 ± 6.25  
CHR-L 5 19.74 ± 13.33 0.62
CHR-M 10 17.19 ± 5.45 0.05
CHR-H 20 18.32 ± 8.86 0.25
ART alone 5 13.95 ± 7.89* 0.01 37.06
ART-CHR-L 5 (1:1) 9.95 ± 5.36* 2.73 × 10−5 0.07 55.10
ART-CHR-M 10 (1:2) 8.75 ± 4.25*,# 2.16 × 10−6 0.04 60.51#
ART-CHR-H 20 (1:4) 11.00 ± 4.98* 2.72 × 10−5 0.18 50.36
  1. * P values of drugs in relation to placebo: P < 0.05
  2. # P values of ART-CHR combination groups in relation to ART alone: P < 0.05