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Table 6 Effects of CHR on cytochrome P450 isoforms in rat liver microsomes in vitro

From: Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

CHR/μM

Enzyme activity (%)

1A2

2A

2C19

2D6

2E1

3A

0

21.64 ± 1.05

14.45 ± 8.11

41.98 ± 0.35

19.25 ± 11.87

69.82 ± 7.31

48.27 ± 4.71

0.5

21.46 ± 2.83*

12.47 ± 1.91

39.56 ± 1.35**

25.62 ± 3.56

66.93 ± 1.82

59.44 ± 2.55**

1.0

17.80 ± 3.07**

12.62 ± 1.35

38.92 ± 0.56**

12.34 ± 12.08

65.76 ± 1.72

57.15 ± 0.93**

1.5

17.93 ± 1.15**

12.92 ± 0.86

37.64 ± 2.31**

12.03 ± 6.33

63.23 ± 2.40

52.02 ± 3.07

2

17.50 ± 0.58**

11.82 ± 1.76

36.14 ± 2.19**

19.81 ± 0.64

63.22 ± 2.06

51.37 ± 0.84

4

10.96 ± 3.56**

10.94 ± 6.85

29.22 ± 1.06**

18.03 ± 4.02

58.21 ± 5.63*

32.94 ± 2.87**

6

12.99 ± 1.56**

15.03 ± 0.33

21.40 ± 3.06**

13.49 ± 10.99

58.79 ± 2.29*

37.18 ± 0.46**

8

11.72 ± 2.81**

15.12 ± 0.96

13.84 ± 0.49**

14.16 ± 7.44

56.44 ± 5.63*

29.70 ± 4.12**

10

6.89 ± 1.56**

15.82 ± 1.62

8.30 ± 1.04**

ND

53.81 ± 2.02*

29.08 ± 3.76**

50

4.05 ± 1.41**

7.79 ± 0.95

0.60 ± 0.11**

ND

34.62 ± 6.25*

18.27 ± 14.55**

  1. ND no detection
  2. Compared with control group (no CHR)
  3. * P < 0.05,** P < 0.01