Skip to main content

Table 6 Effects of CHR on cytochrome P450 isoforms in rat liver microsomes in vitro

From: Impact of chrysosplenetin on the pharmacokinetics and anti-malarial efficacy of artemisinin against Plasmodium berghei as well as in vitro CYP450 enzymatic activities in rat liver microsome

CHR/μM Enzyme activity (%)
1A2 2A 2C19 2D6 2E1 3A
0 21.64 ± 1.05 14.45 ± 8.11 41.98 ± 0.35 19.25 ± 11.87 69.82 ± 7.31 48.27 ± 4.71
0.5 21.46 ± 2.83* 12.47 ± 1.91 39.56 ± 1.35** 25.62 ± 3.56 66.93 ± 1.82 59.44 ± 2.55**
1.0 17.80 ± 3.07** 12.62 ± 1.35 38.92 ± 0.56** 12.34 ± 12.08 65.76 ± 1.72 57.15 ± 0.93**
1.5 17.93 ± 1.15** 12.92 ± 0.86 37.64 ± 2.31** 12.03 ± 6.33 63.23 ± 2.40 52.02 ± 3.07
2 17.50 ± 0.58** 11.82 ± 1.76 36.14 ± 2.19** 19.81 ± 0.64 63.22 ± 2.06 51.37 ± 0.84
4 10.96 ± 3.56** 10.94 ± 6.85 29.22 ± 1.06** 18.03 ± 4.02 58.21 ± 5.63* 32.94 ± 2.87**
6 12.99 ± 1.56** 15.03 ± 0.33 21.40 ± 3.06** 13.49 ± 10.99 58.79 ± 2.29* 37.18 ± 0.46**
8 11.72 ± 2.81** 15.12 ± 0.96 13.84 ± 0.49** 14.16 ± 7.44 56.44 ± 5.63* 29.70 ± 4.12**
10 6.89 ± 1.56** 15.82 ± 1.62 8.30 ± 1.04** ND 53.81 ± 2.02* 29.08 ± 3.76**
50 4.05 ± 1.41** 7.79 ± 0.95 0.60 ± 0.11** ND 34.62 ± 6.25* 18.27 ± 14.55**
  1. ND no detection
  2. Compared with control group (no CHR)
  3. * P < 0.05,** P < 0.01
Back to article page

Malaria Journal

ISSN: 1475-2875

Contact us