CHR/μM | Enzyme activity (%) | |||||
---|---|---|---|---|---|---|
1A2 | 2A | 2C19 | 2D6 | 2E1 | 3A | |
0 | 21.64 ± 1.05 | 14.45 ± 8.11 | 41.98 ± 0.35 | 19.25 ± 11.87 | 69.82 ± 7.31 | 48.27 ± 4.71 |
0.5 | 21.46 ± 2.83* | 12.47 ± 1.91 | 39.56 ± 1.35** | 25.62 ± 3.56 | 66.93 ± 1.82 | 59.44 ± 2.55** |
1.0 | 17.80 ± 3.07** | 12.62 ± 1.35 | 38.92 ± 0.56** | 12.34 ± 12.08 | 65.76 ± 1.72 | 57.15 ± 0.93** |
1.5 | 17.93 ± 1.15** | 12.92 ± 0.86 | 37.64 ± 2.31** | 12.03 ± 6.33 | 63.23 ± 2.40 | 52.02 ± 3.07 |
2 | 17.50 ± 0.58** | 11.82 ± 1.76 | 36.14 ± 2.19** | 19.81 ± 0.64 | 63.22 ± 2.06 | 51.37 ± 0.84 |
4 | 10.96 ± 3.56** | 10.94 ± 6.85 | 29.22 ± 1.06** | 18.03 ± 4.02 | 58.21 ± 5.63* | 32.94 ± 2.87** |
6 | 12.99 ± 1.56** | 15.03 ± 0.33 | 21.40 ± 3.06** | 13.49 ± 10.99 | 58.79 ± 2.29* | 37.18 ± 0.46** |
8 | 11.72 ± 2.81** | 15.12 ± 0.96 | 13.84 ± 0.49** | 14.16 ± 7.44 | 56.44 ± 5.63* | 29.70 ± 4.12** |
10 | 6.89 ± 1.56** | 15.82 ± 1.62 | 8.30 ± 1.04** | ND | 53.81 ± 2.02* | 29.08 ± 3.76** |
50 | 4.05 ± 1.41** | 7.79 ± 0.95 | 0.60 ± 0.11** | ND | 34.62 ± 6.25* | 18.27 ± 14.55** |