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Fig. 1 | Malaria Journal

Fig. 1

From: Associations between hepcidin and immune response in individuals with hyperbilirubinaemia and severe malaria due to Plasmodium vivax infection

Fig. 1

Hepcidin levels discriminate severe malaria and hyperbilirubinaemia from mild malaria. Hepcidin levels were compared in the study groups by the Mann–Whitney test (a). Hepcidin levels were analysed by receiver operating characteristic (ROC) curves to establish the area under the curve (AUC) and the cut-off sensitivity and specificity values to distinguish between individuals with severe malaria or hyperbilirubinaemia and individuals with mild malaria (b). Based on hepcidin cut-off (obtained in b) and median values, a multinomial regression analysis adjusted for age and gender was conducted to calculate odds ratios (ORs) and 95 % confidence intervals (CI), represented by the icons and bars, respectively (c). A p-value <0.05 was considered statistically significant. Mild mal mild malaria group, hyperbil hyperbilirubinaemia group, sev mal severe malaria group

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