Effectiveness of combined chloroquine and primaquine treatment in 14 days versus intermittent single dose regimen, in an open, non-randomized, clinical trial, to eliminate Plasmodium vivax in southern Mexico

Table 6 Comparison of patients with or without Plasmodium vivax recurrent blood infection and the doses of CQ and PQ managed

Treatment regimen	Patients with recurrent P. vivax infection:	n	Total CQ dose/kg Median(IQR)	Total PQ dose/kg Median(IQR)
ISD	No	28^a	9 (8.18–10)	0.625(0.56–0.72)
	Yes	18	9.91 (9–15)	0.69 (0.6–1.0)
	P value^b	0.069		0.107
T14	No	33	26.4(24–29.4)	3.75 (3.33–4.2)
	Yes	4	27.3 (23.6–29.4)	3.82 (3.31–4.11)
	P value^b	0.941		0.941

n number of patients, CQ chloroquine, PQ primaquine
^aThree patients were not included, since after treatment they had an increase in antibody titres but there was no parasite detected by microscopy or PCR; recommended total doses: for ISD, CQ 10 mg/kg and PQ 0.75 mg/kg bw; for T14, CQ 25 mg/kg and PQ 3.5 mg/kg bw
^bWilcoxon rank-sum (Mann–Whitney) test at 95 % CI

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