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Table 3 Difference in IC50 estimates (nM) derived by light microscopy (LM) and flow cytometry (FC)

From: Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry

Anti-malarial P. falciparum P. vivax
n Mean [95 % CI] difference in IC50 LM-FC (nM) Median [Range] difference in IC50 LM-FC (nM) Δ IC50 LM-FC
p valuea
n Mean [95 % CI] difference in IC50 LM-FC (nM) Median [Range] difference in IC50 LM-FC (nM) Δ IC50 LM-FC
p valuea
Chloroquine 54 −3.8 [−10.7 to 3.2] −5.1 [−60.9–59.4] 0.124 21 −4.5 [−16.0 to 7.1] −5.4 [−46.1–60.2] 0.725
Piperaquine 54 6.0 [3.8 to 8.2] 6.1 [−18.7–21.3] <0.001 21 0.7 [−4.6 to 6.0] −4.5 [−15.2–27.5] 0.425
Mefloquine 39 1.3 [−0.6 to 3.1] 0.1 [−5.7–18.6] 0.969 14 1.2 [−3.6 to 6.0] 2.8 [−13.9–15.8] 0.931
Amodiaquine 24 4.0 [1.9 to 6.0] 2.8 [−2.7–15.1] 0.002 13 4.7 [−4.3 to 13.7] 0.4 [−11.8–40.2] 0.864
Artesunate 38 −0.4 [−0.7 to −0.01] −0.25 [−3.6–2.9] 0.077 17 −0.12 [−0.9 to 0.7] −0.45 [−2.2–5.0] 0.102
  1. CI confidence interval
  2. a p-values obtained from paired t- test on log-transformed IC50 derived by LM and FC