From: Quantification of Plasmodium ex vivo drug susceptibility by flow cytometry
Anti-malarial | Mean IC50 (nM) in P. falciparum laboratory linesa | Clinical Plasmodium isolates | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
FC27 (CQ sensitive) | K1 (CQ resistant) | P. falciparum (n = 5) Median IC50 (nM, range) | P. vivax (n = 2) IC50 estimates (nM) | |||||||||
Singleb | Doublec | LMd | Singleb | Doublec | LMd | Singleb | Doublec | LM | Singlee | Doublec | LMd | |
CQ | 25.1 | 23.7 | 20.7 | 171.0 | 167.0 | 159.4 | 85.0 (52.8–165.0) | 97.3 (52.9–179.0) | 108 (65.6–115.0) | 92.2; 132.0 | 88.5; 150.0 | 102.0; 113.0 |
PIP | 32.8 | 32.5 | 34.7 | 63.0 | 63.9 | 89.7 | 35.0 (19.9–45.0) | 38.6 (12.6–57.1) | 47.5 (27.6–68.4) | 79.1; 153.0 | 85.6; 155.0 | 91.8; 115.0 |
MFQ | 46.8 | 40.9 | 49.9 | 16.6 | 14.5 | 9.4 | 10.2 (3.5–19.3) | 10.2 (2.2–23.3) | 9.4 (3.6–15.5) | 23.0; 43.0 | 30.3; 42.4 | 17.7; 22.6 |
AS | 4.1 | 4.3 | 2.6 | 8.7 | 7.8 | 6.0 | 2.2 (1.3–3.1) | 2.2 (1.9–3.7) | 1.9 (1.2–2.6) | 2.6; 6.3 | 2.8; 6.7 | 3.1; 7.8 |