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Table 4 Accuracy indices of the pLDH band compared with expert microscopy and PCR to detect P. falciparum

From: Performance of four HRP-2/pLDH combination rapid diagnostic tests and field microscopy as screening tests for malaria in pregnancy in Indonesia: a cross-sectional study

 

Carestartâ„¢

First Response®

Parascreen®

SD Bioline®

Expert microscopy as the reference

TP, FP

7, 6

6, 7

6, 5

6, 4

FN, TN

17, 904

18, 903

18, 905

18, 906

Sensitivity (95 % CI)

29.2 (13.4–51.2)

25 (10.6–47.1)

25 (10.6–47.1)

25 (10.6–47.1)

Specificity (95 % CI)

99.3 (98.5–99.7)

99.2 (98.3–99.7)

99.5 (98.6–99.8)

99.6 (98.8–99.9)

PPV (95 % CI)

53.8 (26.1–79.6)

46.1 (20.4–73.9)

54.5 (24.6–81.9)

60 (27.4–86.3)

NPV (95 % CI)

98.2 (96.9–98.8)

98.0 (96.7–98.8)

98 (96.9–98.8)

98.1 (96.9–98.8)

LR positive (95 % CI)

44.2 (16.1–121.7)

32.5 (11.8–89.4)

45.5 (14.9–138.8)

56.9 (17.2–188.5)

LR negative (95 % CI)

0.71 (0.55–0.92)

0.76 (0.60–0.95)

0.75 (0.60–0.95)

0.75 (0.60–0.95)

DOR (95 % CI)

62 (16.5–239.0)

43 (11.4–162.7)

60.3 (14.5–257.2)

75.5 (16.9–356.3)

PCR as the reference

TP, FP

7, 6

8, 5

6, 5

7, 3

FN, TN

25, 896

24, 897

26, 897

25, 899

Sensitivity (95 % CI)

21.9 (9.9–40.4)

25 (12.1–43.8)

18.8 (7.9–37.0)

21.9 (9.9–40.4)

Specificity (95 % CI)

99.3 (98.4–99.7)

99.4 (98.6–99.8)

99.4 (98.6–99.8)

99.7 (98.9–99.9)

PPV (95 % CI)

53.8 (26.1–79.6)

61.5 (32.2–84.9)

54.5 (24.6–81.9)

70 (35.4–91.9)

NPV (95 % CI)

97.3 (96.0–98.2)

97.4 (96.1–98.3)

97.2 (95.8–98.1)

97.3 (96.0–98.2)

LR positive (95 % CI)

32.9 (11.7–92.3)

45.1 (15.6–130.2)

33.8 (10.9–105.1)

65.8 (17.8–242.7)

LR negative (95 % CI)

0.79 (0.65–0.94)

0.75 (0.62–0.92)

0.82 (0.69–0.97)

0.78 (0.65–0.94)

DOR (95 % CI)

41.8 (11.5–154.1)

59.8 (16.2–230.7)

41.4 (10.3–169.9)

83.9 (18.0–439.7)

  1. TP true positive, FP false positive, FN false negative, TN true negative, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, DOR diagnostic odds ratio