Skip to main content

Table 4 Accuracy indices of the pLDH band compared with expert microscopy and PCR to detect P. falciparum

From: Performance of four HRP-2/pLDH combination rapid diagnostic tests and field microscopy as screening tests for malaria in pregnancy in Indonesia: a cross-sectional study

  Carestart™ First Response® Parascreen® SD Bioline®
Expert microscopy as the reference
TP, FP 7, 6 6, 7 6, 5 6, 4
FN, TN 17, 904 18, 903 18, 905 18, 906
Sensitivity (95 % CI) 29.2 (13.4–51.2) 25 (10.6–47.1) 25 (10.6–47.1) 25 (10.6–47.1)
Specificity (95 % CI) 99.3 (98.5–99.7) 99.2 (98.3–99.7) 99.5 (98.6–99.8) 99.6 (98.8–99.9)
PPV (95 % CI) 53.8 (26.1–79.6) 46.1 (20.4–73.9) 54.5 (24.6–81.9) 60 (27.4–86.3)
NPV (95 % CI) 98.2 (96.9–98.8) 98.0 (96.7–98.8) 98 (96.9–98.8) 98.1 (96.9–98.8)
LR positive (95 % CI) 44.2 (16.1–121.7) 32.5 (11.8–89.4) 45.5 (14.9–138.8) 56.9 (17.2–188.5)
LR negative (95 % CI) 0.71 (0.55–0.92) 0.76 (0.60–0.95) 0.75 (0.60–0.95) 0.75 (0.60–0.95)
DOR (95 % CI) 62 (16.5–239.0) 43 (11.4–162.7) 60.3 (14.5–257.2) 75.5 (16.9–356.3)
PCR as the reference
TP, FP 7, 6 8, 5 6, 5 7, 3
FN, TN 25, 896 24, 897 26, 897 25, 899
Sensitivity (95 % CI) 21.9 (9.9–40.4) 25 (12.1–43.8) 18.8 (7.9–37.0) 21.9 (9.9–40.4)
Specificity (95 % CI) 99.3 (98.4–99.7) 99.4 (98.6–99.8) 99.4 (98.6–99.8) 99.7 (98.9–99.9)
PPV (95 % CI) 53.8 (26.1–79.6) 61.5 (32.2–84.9) 54.5 (24.6–81.9) 70 (35.4–91.9)
NPV (95 % CI) 97.3 (96.0–98.2) 97.4 (96.1–98.3) 97.2 (95.8–98.1) 97.3 (96.0–98.2)
LR positive (95 % CI) 32.9 (11.7–92.3) 45.1 (15.6–130.2) 33.8 (10.9–105.1) 65.8 (17.8–242.7)
LR negative (95 % CI) 0.79 (0.65–0.94) 0.75 (0.62–0.92) 0.82 (0.69–0.97) 0.78 (0.65–0.94)
DOR (95 % CI) 41.8 (11.5–154.1) 59.8 (16.2–230.7) 41.4 (10.3–169.9) 83.9 (18.0–439.7)
  1. TP true positive, FP false positive, FN false negative, TN true negative, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, DOR diagnostic odds ratio