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Table 6 Accuracy indices of the pLDH bands and Field microscopy compared with expert microscopy and PCR for the detection of P. vivax

From: Performance of four HRP-2/pLDH combination rapid diagnostic tests and field microscopy as screening tests for malaria in pregnancy in Indonesia: a cross-sectional study

  Carestart™ First Response® Parascreen® SD Bioline® Field microscopy Expert microscopy
Expert microscopy as reference test
TP, FP 3, 10 2, 11 2, 9 2, 8 0, 8 N/A
FN, TN 19, 911 11, 910 11, 912 11, 913 13, 913
Sensitivity (95 % CI) 13.6 (3.6–36.0) 15.4 (2.7–46.3) 15.4 (2.7–46.3) 15.4 (2.7–46.3) 0
Specificity (95 % CI) 98.9 (97.9–99.4) 98.8 (97.8–99.4) 99.0 (98.1–99.5) 99.1 (98.2–99.6) 99.1 (98.2–99.6)
PPV (95 % CI) 23.1 (6.2–54.0) 15.4 (2.7–46.3) 18.2 (3.2–52.2) 20.0 (3.5–55.8) 0
NPV (95 % CI) 98.0 (96.8–98.7) 98.8 (97.8–99.4) 98.8 (97.8–99.4) 98.8 (97.8–99.4) 98.6 (97.5–99.2)
LR positive (95 % CI) 12.6 (6.6–68.3) 12.9 (3.2–52.4) 15.7 (3.8–65.9) 17.7 (4.2–75.5) 0
LR negative (95 % CI) 0.87 (0.74–1.03) 0.86 (0.68–1.08) 0.85 (0.68–1.08) 0.85 (0.67–1.07) 1 (1.0–1.0)
DOR (95 % CI) 14.4 (2.9–63.7) 15.0 (2.0–86.3) 18.4 (2.4–109.8) 20.8 (2.7–126.8) 0
PCR as the reference test
TP, FP 3, 10 3, 10 3, 8 2, 8 4, 4 11, 2
FN, TN 20, 901 20, 901 20, 903 21, 903 19, 907 12, 909
Sensitivity (95 % CI) 13.0 (3.4–34.7) 13.0 (3.4–34.7) 13.0 (3.4–34.7) 8.7 (1.5–29.5) 17.4 (5.7–39.5) 47.8 (27.4–68.9)
Specificity (95 % CI) 98.9 (97.9–99.4) 98.9 (97.9–99.4) 99.1 (98.2–99.6) 99.1 (98.2–99.6) 99.6 (98.8–99.9) 99.8 (99.1–100.0)
PPV (95 % CI) 23.1 (6.2–54.0) 23.1 (6.2–54.0) 27.3 (7.3–60.7) 20.0 (3.5–55.8) 50.0 (1.7–82.6) 84.6 (53.7–97.3)
NPV (95 % CI) 97.8 (96.6–98.6) 97.8 (96.6–98.6) 97.8 (96.6–98.6) 97.7 (96.5–98.6) 97.9 (96.8–98.7) 98.7 (97.7–99.3)
LR positive (95 % CI) 11.9 (3.5–40.3) 11.9 (3.5–40.3) 14.9 (4.2–52.4) 9.9 (2.2–44.1) 39.6 (10.6–148.7) 217.8 (51.2–927.5)
LR negative (95 % CI) 0.88 (0.75–1.03) 0.88 (0.75–0.84) 0.88 (0.75–1.03) 0.92 (0.81–1.04) 0.83 (0.69–1.00) 0.52 (0.35–0.77)
DOR (95 % CI) 13.5 (2.7–59.5) 13.5 (2.7–59.5) 16.9 (3.2–78.2) 10.8 (1.5–60.1) 47.7 (9.1–251.4) 416.6 (74.1–3087.2)
  1. TP true positive, FP false positive, FN false negative, TN true negative, CI confidence interval, PPV positive predictive value, NPV negative predictive value, LR likelihood ratio, DOR diagnostic odds ratio