Table 3 Clinical and parasitological outcome variables
Outcome variables | Regimens | ||||||
|---|---|---|---|---|---|---|---|
ARTES (n = 29) | QLD (n = 28) | QNLD3 (n = 30) | QNLD2 (n = 29) | ||||
Mean ± SD | Mean ± SD | p value | Mean ± SD | p value | Mean ± SD | p value | |
Fever clearance time (hours) | 16.8 ± 8.1 | 24.9 ± 13.9 | 0.03 | 31.2 ± 14.3 | <0.001 | 28.6 ± 14.0 | <0.001 |
Coma recovery time (hours) | 40.5 ± 36.1 (n = 2) | 45.0 ± 21.2 (n = 2) | 1.0 | 30.0 ± 15.6 (n = 3) | 1.0 | 36.0 ± 0.0 (n = 2) | 1.0 |
Time to sit unsupported (hours) | 7.7 ± 5.4 (n = 13) | 13.9 ± 1.8 (n = 7) | 0.7 | 15.9 ± 2.3 (n = 6) | 0.4 | 17.3 ± 1.9 (n = 9) | 0.7 |
Time to eat (hours) | 4.1 ± 3.8 (n = 14) | 6.2 ± 2.7 (n = 12) | 0.1 | 8.7 ± 2.5 (n = 8) | 0.07 | 11.3 ± 2.3 (n = 9) | 0.06 |
Time to exit from the protocol (hours) | 28.6 ± 10.3 | 34.3 ± 12.8 | 0.01 | 37.4 ± 17.3 | 0.002 | 36.7 ± 12.4 | 0.01 |
PCT (hours) | 19.2 ± 11.3 | 29.3 ± 18.0 | 0.03 | 36.4 ± 21.2 | <0.001 | 29.5 ± 19.2 | <0.001 |
PRR24 (%) | 92.0 ± 10.4 (n = 9) | 74.8 ± 24.0 (n = 18) | 0.03 | 66.5 ± 22.0 (n = 22) | <0.001 | 71.7 ± 23.7 (n = 22) | 0.03 |