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Table 3 Clinical and parasitological outcome variables

From: A randomized trial of the efficacy of artesunate and three quinine regimens in the treatment of severe malaria in children at the Ebolowa Regional Hospital, Cameroon

Outcome variables Regimens
ARTES (n = 29) QLD (n = 28) QNLD3 (n = 30) QNLD2 (n = 29)
Mean ± SD Mean ± SD p value Mean ± SD p value Mean ± SD p value
Fever clearance time (hours) 16.8 ± 8.1 24.9 ± 13.9 0.03 31.2 ± 14.3 <0.001 28.6 ± 14.0 <0.001
Coma recovery time (hours) 40.5 ± 36.1 (n = 2) 45.0 ± 21.2 (n = 2) 1.0 30.0 ± 15.6 (n = 3) 1.0 36.0 ± 0.0 (n = 2) 1.0
Time to sit unsupported (hours) 7.7 ± 5.4 (n = 13) 13.9 ± 1.8 (n = 7) 0.7 15.9 ± 2.3 (n = 6) 0.4 17.3 ± 1.9 (n = 9) 0.7
Time to eat (hours) 4.1 ± 3.8 (n = 14) 6.2 ± 2.7 (n = 12) 0.1 8.7 ± 2.5 (n = 8) 0.07 11.3 ± 2.3 (n = 9) 0.06
Time to exit from the protocol (hours) 28.6 ± 10.3 34.3 ± 12.8 0.01 37.4 ± 17.3 0.002 36.7 ± 12.4 0.01
PCT (hours) 19.2 ± 11.3 29.3 ± 18.0 0.03 36.4 ± 21.2 <0.001 29.5 ± 19.2 <0.001
PRR24 (%) 92.0 ± 10.4 (n = 9) 74.8 ± 24.0 (n = 18) 0.03 66.5 ± 22.0 (n = 22) <0.001 71.7 ± 23.7 (n = 22) 0.03
  1. Significant p values are in italics
  2. PCT Parasite clearance time, PRR 24 Parasite reduction rate at H24