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Table 2 Characteristics of 1134 pregnancies by ACT exposure status [n (%) otherwise stated]

From: Risks of miscarriage and inadvertent exposure to artemisinin derivatives in the first trimester of pregnancy: a prospective cohort study in western Kenya

 

Overall (N = 1134)

No ACT exposure in the first trimester (N = 835)

Unconfirmed ACT exposure in the first trimester (N = 222)

Confirmed ACT exposure in the first trimester (N = 77)

P values*

Age in years [mean (SD; range)]

26.1 (6.8; 15–47)

26.1 (6.7; 15–45)

26.7 (7.2; 15–47)

25.2 (6.5; 16–41)

0.225

Gravidity

Missing n = 16

Missing n = 14

Missing n = 1

Missing n = 1

0.065

Primigravidae

219 (19.6)

151 (18.4)

47 (21.3)

21 (27.6)

 

1–3 pregnancies

525 (47.0)

405 (49.3)

90 (40.7)

30 (39.5)

 

4+ pregnancies

374 (33.5)

265 (32.3)

84 (38.0)

25 (32.9)

 

Previous pregnancy loss

160 (14.3), Missing n = 17

118 (14.4), Missing n = 15

30 (13.6), Missing n = 1

12 (15.8), Missing n = 1

0.888

Gestational age at detection in weeks [mean (SD; range)]a

13.3 (6.9; 0–27.9)

13.3 (7.0; 0–27.9)

13.0 (6.7; 0.3–27)

13.6 (7.1; 2.4–27.4)

0.770

Occupation

Missing n = 31

Missing n = 28

Missing n = 1

Missing n = 2

0.191

Not working

379 (34.4)

281 (34.8)

68 (30.8)

30 (40.0)

 

Farming

369 (33.5)

268 (33.2)

80 (36.2)

21 (28.0)

 

Small business/Skilled Labour

335 (30.4)

246 (30.5)

65 (29.4)

24 (32.0)

 

Other

20 (1.8)

12 (1.5)

8 (3.6)

0

 

Antenatal care summary

 Number of ANC visit

Missing n = 39

Missing n = 31

Missing n = 5

Missing n = 3

0.125

 None

89 (8.1)

64 (8.0)

21 (9.7)

4 (5.4)

 

 1

90 (8.2)

61 (7.6)

24 (11.1)

5 (6.8)

 

 2

155 (14.2)

121 (15.1)

25 (11.5)

9 (12.2)

 

 3

244 (22.3)

193 (24.0)

38 (17.5)

13 (17.6)

 

 4+

517 (47.2)

365 (45.4)

109 (50.2)

43 (58.1)

 

Gestational age at first ANC visit in weeks [mean (SD)]*

20.8 (7.8) range: 1.7–41.0

21.24 (7.8) range: 2.7–41.0

19.7 (7.6) range: 1.7–41.0

19.4 (7.7) range: 3.4-37.0

0.020

HIV positiveb

Missing n = 101

Missing n = 79

Missing n = 18

Missing n = 4

0.354

Negative

771 (74.4)

562 (74.3)

149 (73.0)

60 (82.2)

 

Positive

262 (25.4)

194 (25.7)

55 (27.0)

13 (17.8)

 
  1. ACT artemisinin combination therapy, SD standard deviation
  2. * P values refer to Pearson Chi square test for categorical variables and ANOVA test for continuous variables
  3. aGestational age lowest estimate include 0 which reflects inaccuracy in the gestational age measurements
  4. bHIV status information was not available for 12 % (129) of pregnancies that did not attend antenatal care or have the antenatal card for review. HIV status information was complemented by HDSS and data which offered home-based HIV testing and counselling to PBIDS participants. Test results were linked to the study participants using unique ID and missing data were updated if the test was performed before the pregnancy detection for HIV positive test results and for HIV negative results if the test was performed maximum 3 months before or after pregnancy detection. An additional 30 HIV status were ascertained while 8 % (99) still had no HIV status data
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Malaria Journal

ISSN: 1475-2875

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