Fig. 2
From: Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy
Chloroquine exposure significantly decreases the deformability of trophozoites-infected red blood cells in a dose- and time-dependent manner. a Purified trophozoites were incubated with a range of chloroquine concentrations for 4 h. Each data point represents the transit pressure for one trophozoite iRBC and a significant increase in transit pressure was observed a 1 and 1.5 µM. b Purified trophozoites were incubated with 1 µM chloroquine for at 2, 4 or 7 h. Treated and untreated iRBCs showed time-dependent loss of deformability, with a significant increase in transit pressure by 4 h (p = 0.0026), compared to untreated iRBCs. c There is a positive correlation between the median transiting pressure of iRBCs incubated with (R2 = 0.9784) and without (R2 = 0.8946) chloroquine treatment and time of incubation