From: Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy
Drug name | Concentration (≥4 × EC50) | Median normalized deformability | % Median increase in deformability | P value |
---|---|---|---|---|
Chloroquine | 1 µM | 1.41 | 41 | <0.0001 |
Mefloquine | 1 µM | 1.22 | 22 | 0.0002 |
Pyrimethamine | 20Â nM | 1.80 | 80 | <0.0001 |
Proguanil | 100 µM | 1.58 | 58 | 0.0052 |
Artesunate | 10Â nM | 1.29 | 29 | 0.0022 |
Artemether | 8Â nM | 1.95 | 95 | <0.0001 |
Dihydroartemisinin | 20Â nM | 2.11 | 111 | <0.0001 |
Tetracycline | 100 µM | 0.93 | −7 | ns |
Atovaquone | 250Â nM | 1.46 | 46 | 0.0001 |
(+)-SJ733 | 1.08 µM | 5.54 | 454 | <0.0001 |
(−)-SJ733 | 1.08 µM | 0.90 | −10 | ns |
NITD246 | 3.6Â nM | 3.34 | 234 | <0.0001 |