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Table 1 Individual concentrations and deformability values that were normalized to DMSO or ddH2O control for respective anti-malarial drug treatments

From: Reduced deformability of parasitized red blood cells as a biomarker for anti-malarial drug efficacy

Drug name

Concentration (≥4 × EC50)

Median normalized deformability

% Median increase in deformability

P value

Chloroquine

1 µM

1.41

41

<0.0001

Mefloquine

1 µM

1.22

22

0.0002

Pyrimethamine

20 nM

1.80

80

<0.0001

Proguanil

100 µM

1.58

58

0.0052

Artesunate

10 nM

1.29

29

0.0022

Artemether

8 nM

1.95

95

<0.0001

Dihydroartemisinin

20 nM

2.11

111

<0.0001

Tetracycline

100 µM

0.93

−7

ns

Atovaquone

250 nM

1.46

46

0.0001

(+)-SJ733

1.08 µM

5.54

454

<0.0001

(−)-SJ733

1.08 µM

0.90

−10

ns

NITD246

3.6 nM

3.34

234

<0.0001