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Table 2 P. falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) haplotypes by study sites

From: High-level Plasmodium falciparum sulfadoxine-pyrimethamine resistance with the concomitant occurrence of septuple haplotype in Tanzania

Gene haplotype Prevalence of haplotypes by sites
Muheza (n = 77) Muleba (n = 72) Nachingwea (n = 85) P value
Pfdhfr CNCSI 0 (0) 0 (0) 3 (3.5) 0.109
CICNI 4 (5.2) 17 (23.6) 7 (8.4) 0.002
CIRSI 1 (1.3) 0 (0) 0 (0) 0.642
CNRNI 0 (0) 1 (1.4) 15 (17.7) <0.001
CIRNI 72 (93.3) 54 (75.0) 60 (70.6) <0.001
   n = 77 n = 72 n = 82  
Pfdhps SAKAA 1 (1.3) 11 (15.3) 11 (16.5) 0.003
AAKAA 4 (5.2) 4 (5.6) 16 (18.8) 0.008
SAKAS 0 (0) 1 (1.4) 0 (0) 0.308
SAEAA 0 (0) 4 (5.6) 0 (0) 0.008
AAKAS 0 (0) 1 (1.4) 1 (1.2) 0.76
SGEAA 21 (27.2) 15 (20.8) 0 (0) <0.001
SGEGA 31 (40.3) 2 (2.8) 0 (0) <0.001
AGEAA 12 (15.6) 30 (41.7) 54 (63.5) <0.001*
AGEGA 8 (10.4) 4 (5.6) 0 (0) 0.003
  1. Bold underline indicates the amino acid changes
  2. n number of haplotypes excluding the mixed infections/genotypes
  3. * Pearson Chi-square test was applied (χ2 = 39.9, p < 0.001), all others were compared using Fisher’s exact test