Table 2 P. falciparum dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pfdhps) haplotypes by study sites
Gene haplotype | Prevalence of haplotypes by sites | ||||
|---|---|---|---|---|---|
Muheza (n = 77) | Muleba (n = 72) | Nachingwea (n = 85) | P value | ||
Pfdhfr | CNCSI | 0 (0) | 0 (0) | 3 (3.5) | 0.109 |
CICNI | 4 (5.2) | 17 (23.6) | 7 (8.4) | 0.002 | |
CIRSI | 1 (1.3) | 0 (0) | 0 (0) | 0.642 | |
CNRNI | 0 (0) | 1 (1.4) | 15 (17.7) | <0.001 | |
CIRNI | 72 (93.3) | 54 (75.0) | 60 (70.6) | <0.001 | |
|  |  | n = 77 | n = 72 | n = 82 |  |
|---|---|---|---|---|---|
Pfdhps | SAKAA | 1 (1.3) | 11 (15.3) | 11 (16.5) | 0.003 |
AAKAA | 4 (5.2) | 4 (5.6) | 16 (18.8) | 0.008 | |
SAKAS | 0 (0) | 1 (1.4) | 0 (0) | 0.308 | |
SAEAA | 0 (0) | 4 (5.6) | 0 (0) | 0.008 | |
AAKAS | 0 (0) | 1 (1.4) | 1 (1.2) | 0.76 | |
SGEAA | 21 (27.2) | 15 (20.8) | 0 (0) | <0.001 | |
SGEGA | 31 (40.3) | 2 (2.8) | 0 (0) | <0.001 | |
AGEAA | 12 (15.6) | 30 (41.7) | 54 (63.5) | <0.001* | |
AGEGA | 8 (10.4) | 4 (5.6) | 0 (0) | 0.003 |