Tetracyclines in malaria

Malaria Journal

Table 1 Efficacy of doxycycline for prophylaxis against P. falciparum malaria

Year	Place	References	Pop	Number	Drug	Route	Dose/d	Other drug	Duration/d	Efficacity
1987	Thailand	Pang [54]	C	95	D	PO	50 or 100 mg^a	/	35	94.7
1988	Thailand	Pang [55]	C	67	D	PO	50 or 100 mg^a	/	97	97.0
1988	Thailand	Pang [55]	C	77	D	PO	25 or 50 mg^a	/	107	97.4
1989	Thailand	Watanasook [56]	A	243	D	PO	50 mg	/	119	92.6
1989	Thailand	Watanasook [56]	A	243	D	PO	100 mg	/	119	84.4
1992	Thailand	Shanks [57]	A	77	D	PO	100 mg	/	80	96.1
1993	New Guinea	Rieckmann [47]	A	60	D	PO	100 mg	/	42	100
1993	New Guinea	Rieckmann [47]	A	69	D	PO	100 mg	PR	21	100
1993	New Guinea	Rieckmann [47]	A	125	D	PO	50 mg	CQ	91	100
1995	Kenya	Weiss [60]	C	32	D	PO	50 mg	/	77	84
1995	Somalia	Shanks [63]	A	900	D	PO	100 mg	/	135	99.9
1995	Cambodia	Shanks [63]	A	600	D	PO	100 mg	CQ	195	99.7
1995	New Guinea	Shanks [59]	A	53	D	PO	100 mg	PR	42	96.2
1997	Irian Jaya	Ohrt [103]	A	67	D	PO	100 mg	/	87	99
1998	Kenya	Andersen [104]	A	70	D	PO	100 mg	/	70	92.6
1999	Irian Jaya	Taylor [58]	A	75	D	PO	100 mg	/	140	96.3
1999	Gabon +CAR	Baudon [15]	A	171	D	PO	100 mg	/	150	97.1
1999	Ethiopia	Schwartz [105]	A	19	D	PO	100 mg	/	/	94.7
2002	Eastern Timor	Peragallo [106]	A	280	D	PO	100 mg	PR	168	98.4
2005	Afghanistan	Sonmez [19]	A	986	D	PO	100 mg	/	84	100

Pop population, A adults, C children, D doxycycline, CQ chloroquine, PR primaquine
^aAccording to weight (< or >40 kg)

ISSN: 1475-2875