Malaria Journal

Table 3 Clinical trials of cycline plus other drug against P. falciparum malaria

From: Tetracyclines in malaria

Study demographic details					Regimen								Efficacy (%)
Year	Place	References	Pop	Nb	Cycline			Other Drug			Route	Days
Year	Place	References	Pop	Nb	Dosage/day	Drug	Nb doses/day	Drug	Dosage/day	Nb doses/day	Route	Days
1972	Thailand	Colwell [109]	A	30	1000 mg	T	4	Q	1920 mg	3	PO	3 + 10	96.7
1973	Thailand	Chin [69]	A	12	NR	T	NR	Q	NR	NR	PO	NR	66.7
1973	Thailand	Chin [69]	A	13	NR	T	NR	QPy	NR	NR	PO	NR	66.7
1973	Thailand	Colwell [70]	A	32	NR	T	NR	Q	NR	NR	PO	NR	84
1983	Thailand	Noeypatimanond [71]	AC	51	NR	T	NR	Am	NR	NR	PO	NR	96
1988	Cambodia	Giboda [110]	A	22	1500 mg	T	3	Q	1500 mg	3	PO	7/10	100
1994	Thailand	Looreesuwan [111]	A	50	1000 mg	T	4	M	1250 mg	2	PO	7/1	94
1994	Thailand	Looreesuwan [111]	A	52	1000 mg	T	4	Q	1800 mg	3	PO	7	98
1994	Thailand	Looreesuwan [112]	A	54	200 mg	D	1	M	1250 mg	2	PO	7/1	96
1994	Thailand	Looreesuwan [112]	A	55	200 mg	D	1	A	100 mg	2	PO	7/2.5	80
1995	Gabon	Metzger [113]	A	35	4 mg/kg	D	2	Q	24 mg/kg	1	PO	3/1.5	91
1996	Thailand	Na-Bangchang [114]	A	30	200 mg	D	2	A	400 mg	2	PO	5/1	53.3
1996	Thailand	Looreesuwan [115]	A	25	1000 mg	T	4	At	2250 mg	3	PO	7/1.3	100
1996	Thailand	Looreesuwan [115]	A	22	200 mg	D	2	A	1000 mg	2	PO	3	91
1996	Brazil	Duarte [116]	AC	88	1500 mg	T	3	A	100 mg	2	PO	7	80
1996	Brazil	Duarte [116]	AC	88	1500 mg	T	3	Q	2000 mg	2	PO	7/3	77
1996	Thailand	Bunnag [117]	A	46	1000 mg	T	4	Q	1800 mg	3	PO	5	87
1996	Thailand	Bunnag [117]	A	40	1000 mg	T	4	Q	1800 mg	3	PO	7	100
2000	Thailand	Pukrittayakamee [118]	AC	68	16 mg/kg	T	4	Q	30 mg/kg	3	PO	7	98
2001	Indonesia	Taylor [108]	A	39	200 mg	D	2	CQ	STD	1	PO	7/3	90.9
2004	Thailand	Pukrittayakamee [72]	A	30	16 mg/kg	T	4	Q	30 mg/kg	3	PO	7	100
2006	Brazil	Alecrim [74]	A	31	200 mg	D	2	Q	1500 mg	3	PO	3 + 2	100
2007	Pakistan	Ejaz [119]	A	100	200 mg	D	2	Q	30 mg/kg	3	PO	3 + 4	100

Pop population, A adult, C children, P pregnant women, A artesunate, Am amodiaquine, At atovaquone, C chloroquine, D doxycycline, M mefloquine, Q quinine, Py pyrimethamine, T tetracycline, STD standard, i.e. 10 mg/kg on day 0 and 1 and 5 mg/kg on day 2, NR not reported

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ISSN: 1475-2875

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