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Table 4 Fever clearance time (FCT)

From: Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study

Statistical summary

Age group 1 (6 months to <2 years)

Age group 2 (2 to <6 years)

Age group 3 (6 to ≤12 years)

 Censored

3 (13.6 %)

6 (12.2 %)

3 (4.3 %)

Summary (excluding censored values)

 n

19

43

67

 Mean ± SD

12.9 ± 9.37

9.1 ± 8.63

9.1 ± 7.86

 Min, max

0, 36

0, 25

0, 30

Time to fever clearance (h)

 

 Quartile estimate (95 % confidence interval)

 

  25 %

6.0 (6.0, 12.0)

0.0 (0.0, 6.0)

4.0 (0.0, 6.0)

  50 % (median)

12.0 (6.0, 19.0)

12.0 (6.0, 18.0)

6.0 (6.0, 12.0)

  75 %

24.0 (12.0, NE)

18.0 (18.0, 24.0)

18.0 (12.0, 18.0)

  Mean

16.0

11.0

10.0

  1. Overall, median FCT was estimated to be 10.0 h (4.0–18.0 h)
  2. NE not estimable