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Table 6 Mean pharmacokinetic parameters following 3 day oral administration of arterolane maleate and piperaquine phosphate

From: Efficacy and safety of fixed dose combination of arterolane maleate and piperaquine phosphate dispersible tablets in paediatric patients with acute uncomplicated Plasmodium falciparum malaria: a phase II, multicentric, open-label study

Analyte Parameters Cmax
(ng/mL)
AUClast (ng h/mL) AUC48-72 (ng h/mL) t1/2 (h)
n 50 50 48 26
Arterolane maleate AM 90.68 1507.93 688.29 3.30
Median 83.65 1209.30 615.25 3.24
Minimum 23.38 110.74 137.71 2.04
Maximum 204.96 6174.14 1696.75 5.48
  n 50 50 48 48
Piperaquine phosphate AM 578.97 58,472.41 7333.04 292.72
Median 497.77 50,453.06 6417.42 221.48
Minimum 58.71 965.76 2337.00 94.60
Maximum 1604.18 169,956.99 20,590.96 801.86
  1. AM arithmetic mean