Skip to main content

Table 2 Antiplasmodial activity of ethanol bark extract of Aspidosperma parvifolium, fractions and uleine along with literature data for apparicine, aspidocarpine, and ellipticine

From: Aspidosperma species as sources of anti-malarials: uleine is the major anti-malarial indole alkaloid from Aspidosperma parvifolium (Apocynaceae)

Extract/fractions/compounds

IC50 (µg/mL) P. falciparum W2

IC50 (µg/mL) P. falciparum 3D7

MM

HM

HRPII

MM

HM

Choroquine

0.02 ± 0.002

0.018 ± 0.0005

0,0856 ± 0.0201

0.0013 ± 0.0001

0.002 ± 0.0004

Mefloquine

0.016 ± 0.002

0.044 ± 0.008

ND

0.048 ± 0.0007

0.052 ± 0.0006

EEAP

32.75 ± 1.06

42.51 ± 6.33

10,11 ± 2,22

20.51 ± 0.70

38.20 ± 0.33

EEAPA

0.98 ± 0.20

8.0 ± 1.19

0.43 ± 0.11

7.63 ± 0.31

43.05 ± 4.30

EEAPN

15.02 ± 2.83

38.02 ± 3.76

9,71 ± 2,63

17.75 ± 0.35

18.2 ± 1.75

Uleine

0.75 ± 0.10

8.78a

2.95 ± 1.47

11.90 ± 0.10

ND

Apparicineb

 

3.0 ± 1.4

3.2 ± 2.7

  

Aspidocarpineb

 

5.4 ± 2.5

4.4 ± 0.8

  

Ellipticinec

0.018

    
  1. EEAP ethanol extract of Aspidosperma parvifolium trunk bark, EEAPA alkaloid fraction prepared from EEAP, EEAPN neutral fraction prepared from EEAP, MM microscopic method, HM [3H]-hypoxanthine method, ND not determined
  2. aone triplicate experiment
  3. bRef. [36] P. falciparum W2
  4. cRef. [35] P. falciparum K1