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Table 2 Antiplasmodial activity of ethanol bark extract of Aspidosperma parvifolium, fractions and uleine along with literature data for apparicine, aspidocarpine, and ellipticine

From: Aspidosperma species as sources of anti-malarials: uleine is the major anti-malarial indole alkaloid from Aspidosperma parvifolium (Apocynaceae)

Extract/fractions/compounds IC50 (µg/mL) P. falciparum W2 IC50 (µg/mL) P. falciparum 3D7
MM HM HRPII MM HM
Choroquine 0.02 ± 0.002 0.018 ± 0.0005 0,0856 ± 0.0201 0.0013 ± 0.0001 0.002 ± 0.0004
Mefloquine 0.016 ± 0.002 0.044 ± 0.008 ND 0.048 ± 0.0007 0.052 ± 0.0006
EEAP 32.75 ± 1.06 42.51 ± 6.33 10,11 ± 2,22 20.51 ± 0.70 38.20 ± 0.33
EEAPA 0.98 ± 0.20 8.0 ± 1.19 0.43 ± 0.11 7.63 ± 0.31 43.05 ± 4.30
EEAPN 15.02 ± 2.83 38.02 ± 3.76 9,71 ± 2,63 17.75 ± 0.35 18.2 ± 1.75
Uleine 0.75 ± 0.10 8.78a 2.95 ± 1.47 11.90 ± 0.10 ND
Apparicineb   3.0 ± 1.4 3.2 ± 2.7   
Aspidocarpineb   5.4 ± 2.5 4.4 ± 0.8   
Ellipticinec 0.018     
  1. EEAP ethanol extract of Aspidosperma parvifolium trunk bark, EEAPA alkaloid fraction prepared from EEAP, EEAPN neutral fraction prepared from EEAP, MM microscopic method, HM [3H]-hypoxanthine method, ND not determined
  2. aone triplicate experiment
  3. bRef. [36] P. falciparum W2
  4. cRef. [35] P. falciparum K1
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Malaria Journal

ISSN: 1475-2875

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