Fig. 4

Titration of the capacity to inhibit formation of Palo Alto 89F5 VarO rosettes (a) or disrupt Palo Alto 89F5 VarO rosettes (b). The capacity of each mAb to inhibit rosette formation or disrupt rosettes was studied as described in the “Methods” section. Assays were done on at least three distinct parasite cultures. A typical example is shown. The rosetting rate for each mAb concentration was recorded by microscopic examination and the results expressed as percent of rosettes observed in a test culture compared to a culture done in the absence of added mouse or rabbit reagent