Table 3 Prevalence of genetic markers associated with drug resistance
Year | Gene | SNP’s | n | Allele % | ||
|---|---|---|---|---|---|---|
Wild-type | Mutant | Mixed allele | ||||
2011 | pfmdr1 | N86Y | 28 | 68 % (n = 19) | 21 % (n = 6) | 11 % (n = 3) |
D1246Y | 31 | 100 % | 0 | 0 | ||
>copy | 4/32 (12.5 %) | |||||
pfatp6 | S769N | 37 | 100 % | 0 | 0 | |
K13 | Y493H | 5 | 100 % | 0 | 0 | |
R539T | 5 | 100 % | 0 | 0 | ||
I543T | 5 | 100 % | 0 | 0 | ||
C580Y | 5 | 100 % | 0 | 0 | ||
2012 | pfmdr1 | N86Y | 33 | 69.7 % (n = 23) | 18.2 % (n = 6) | 12.1 % (n = 4) |
D1246Y | 32 | 97 % (n = 3) | 3 % (n = 1) | 0 | ||
>copy | 4/29 (13.8 %) | |||||
pfatp6 | S769 N | 33 | 100 % | 0 | 0 | |
K13 | Y493H | 7 | 100 % | 0 | 0 | |
R539T | 7 | 100 % | 0 | 0 | ||
I543T | 7 | 100 % | 0 | 0 | ||
C580Y | 7 | 100 % | 0 | 0 | ||
2013 | pfmdr1 | N86Y | 33 | 82 % (n = 27) | 15 % (n = 5) | 3 % (n = 1) |
D1246Y | 33 | 100 % | 0 | 0 | ||
>copy | 5/32 (15.6 %) | |||||
pfatp6 | S769 N | 33 | 100 % | 0 | 0 | |
K13 | Y493H | 9 | 100 % | 0 | 0 | |
R539T | 9 | 100 % | 0 | 0 | ||
I543T | 9 | 100 % | 0 | 0 | ||
C580Y | 9 | 100 % | 0 | 0 | ||
Total | pfmdr1 | N86Y | 94 | 73.4 (n = 69) | 18.1 % (n = 17) | 8.5 % (n = 8) |
D1246Y | 96 | 99 (n = 86) | 1 (n = 1) | 0 | ||
>copy | 13/93 (14 %) | |||||
pfatp6 | S769N | 103 | 100 % (n = 103) | 0 | 0 | |
K13 | Y493H | 21 | 100 % | 0 | 0 | |
R539T | 21 | 100 % | 0 | 0 | ||
I543T | 21 | 100 % | 0 | 0 | ||
C580Y | 21 | 100 % | 0 | 0 | ||