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Table 4 Correlation between SNP frequencies and treatment outcomes

From: Evaluation of artemether-lumefantrine efficacy in the treatment of uncomplicated malaria and its association with pfmdr1, pfatpase6 and K13-propeller polymorphisms in Luanda, Angola

Treatment outcome SNPs pfmdr1 >copy
pfmdr1 86 pfmdr1 1246 Pfatp6 769 pfK13
N86 86Y 86 N + Y D1246 1246Y S769 769 N wt mutant
ACPR 74.1 % (n = 63) 17.6 % (n = 15) 8.2 % (n = 7) 99 % (n = 88) 1 % (n = 1) 100 % (n = 93) 0 100 % (n = 12) 0 13 % (n = 12/92)
Treatment failure 66.6 % (n = 6) 22.2 % (n = 2) 11.1 % (n = 1) 100 (n = 7) 0 100 % (n = 10) 0 100 % (n = 9) 0 11 % (n = 1/9)
Total (n) 69 17 8 95 1 103 0 21 0 13
  1. pfmdr1, Plasmodium falciparum multidrug resistance 1 gene, SNP, Single nucleotide polymorphism, Pfatp6, Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase6 gene, K13, mutations in the PF3D7_1343700 kelch propeller domain (‘K13-propeller’); wt, wild type allele; mixed, mix infections, >copy, pfmdr1 amplifyed (with >1 copy)