From: Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model
Parameters
Compound 1
Compound 2
T1/2 (h)
4.3 ± 1.02
0.7 ± 0.2
Vss (l/kg)
20.1 ± 6
154.1 ± 1
CL (ml/min/kg)
27.6 ± 8
366 ± 46.6
AUC0–∞ (µM min)
196 ± 29.9
25.2 ± 3.4