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Table 3 Pharmacokinetic parameters of hydroxypyridone-chloroquine hybrids after intravenous administration

From: Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

Parameters

Compound 1

Compound 2

T1/2 (h)

4.3 ± 1.02

0.7 ± 0.2

Vss (l/kg)

20.1 ± 6

154.1 ± 1

CL (ml/min/kg)

27.6 ± 8

366 ± 46.6

AUC0–∞ (µM min)

196 ± 29.9

25.2 ± 3.4

  1. Data represent mean ± standard deviation of data points obtained from five uninfected mice
  2. ND indicate that the value was not determined