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Table 3 Pharmacokinetic parameters of hydroxypyridone-chloroquine hybrids after intravenous administration

From: Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model

Parameters Compound 1 Compound 2
T1/2 (h) 4.3 ± 1.02 0.7 ± 0.2
Vss (l/kg) 20.1 ± 6 154.1 ± 1
CL (ml/min/kg) 27.6 ± 8 366 ± 46.6
AUC0–∞ (µM min) 196 ± 29.9 25.2 ± 3.4
  1. Data represent mean ± standard deviation of data points obtained from five uninfected mice
  2. ND indicate that the value was not determined