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Table 2 Prevalence of genotypes of pfdhfr, pfdhps, and combined pfdhfrpfdhps genes in P. falciparum isolates from Hadhramout, Yemen

From: Frequencies distribution of dihydrofolate reductase and dihydropteroate synthetase mutant alleles associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum population from Hadhramout Governorate, Yemen

Gene/genotypea Prevalence n (%) Total
n = 128
P value
Hajer
n = 26
Al-Raydah-Qusyer
n = 102
Pfdhfr
 N51C59S108I164 7 (26.9) 14 (13.7) 21 (17) 0.105
 I 51C59 N 108I164 19 (73.1) 87 (85.3) 106 (82.8) 0.140
 I 51 R 59 N 108I164 0 (0) 1 (1) 1 (0.8) 0.797b
Gene/genotypea Prevalence n (%) Total
n = 114
P value
Hajer
n = 25
Al-Raydah-Qusyer
n = 89
Pfdhps
S436A437K540 16 (64) 47 (52.8) 63 (55.3)  
 S436 G 437K540 9 (36) 42 (47.2) 51 (44.7) 0.56
Gene/genotypea Prevalence n (%) Total
n = 107
P value
Hajer
n = 25
Al-Raydah-Qusyer
n = 82
Pfdhfrpfdhps
 N51C59S108I164-S436A437K540 5 (20) 8 (9.8) 13 (12.1) 0.170
 N51C59S108I164-S436 G 437K540 1 (4) 4 (4.8) 5 (4.7) 1.000b
 I 51C59 N 108I164-S436A437K540 11 (44) 35 (42.7) 46 (43) 0.907
 I 51C59 N 108I164-S436 G 437K540 8 (32) 34 (41.5) 42 (39.3) 0.396
 I 51 R 59 N 108I164-S436 G 437K540 0 (00) 1 (1.2) 1 (0.9) 1.000b
  1. n sample size, NA not applicable
  2. aMutant alleles are bold and underlined
  3. bThe difference was examined using Fisher exact test