Frequencies distribution of dihydrofolate reductase and dihydropteroate synthetase mutant alleles associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum population from Hadhramout Governorate, Yemen

Table 2 Prevalence of genotypes of pfdhfr, pfdhps, and combined pfdhfr–pfdhps genes in P. falciparum isolates from Hadhramout, Yemen

Gene/genotype^a	Prevalence n (%)		Total n = 128	P value
Gene/genotype^a	Hajer n = 26	Al-Raydah-Qusyer n = 102	Total n = 128	P value
Pfdhfr
N₅₁C₅₉S₁₀₈I₁₆₄	7 (26.9)	14 (13.7)	21 (17)	0.105
I ₅₁C₅₉ N ₁₀₈I₁₆₄	19 (73.1)	87 (85.3)	106 (82.8)	0.140
I ₅₁ R ₅₉ N ₁₀₈I₁₆₄	0 (0)	1 (1)	1 (0.8)	0.797^b

Gene/genotype^a	Prevalence n (%)		Total n = 114	P value
Gene/genotype^a	Hajer n = 25	Al-Raydah-Qusyer n = 89	Total n = 114	P value
Pfdhps
S₄₃₆A₄₃₇K₅₄₀	16 (64)	47 (52.8)	63 (55.3)
S₄₃₆ G ₄₃₇K₅₄₀	9 (36)	42 (47.2)	51 (44.7)	0.56

Gene/genotype^a	Prevalence n (%)		Total n = 107	P value
Gene/genotype^a	Hajer n = 25	Al-Raydah-Qusyer n = 82	Total n = 107	P value
Pfdhfr–pfdhps
N₅₁C₅₉S₁₀₈I₁₆₄-S₄₃₆A₄₃₇K₅₄₀	5 (20)	8 (9.8)	13 (12.1)	0.170
N₅₁C₅₉S₁₀₈I₁₆₄-S₄₃₆ G ₄₃₇K₅₄₀	1 (4)	4 (4.8)	5 (4.7)	1.000^b
I ₅₁C₅₉ N ₁₀₈I₁₆₄-S₄₃₆A₄₃₇K₅₄₀	11 (44)	35 (42.7)	46 (43)	0.907
I ₅₁C₅₉ N ₁₀₈I₁₆₄-S₄₃₆ G ₄₃₇K₅₄₀	8 (32)	34 (41.5)	42 (39.3)	0.396
I ₅₁ R ₅₉ N ₁₀₈I₁₆₄-S₄₃₆ G ₄₃₇K₅₄₀	0 (00)	1 (1.2)	1 (0.9)	1.000^b