Lipid metabolites of the phospholipase A2 pathway and inflammatory cytokines are associated with brain volume in paediatric cerebral malaria

Table 2 Plasma metabolites associated with brain volume in Malawian children with retinopathy positive CM

Metabolite	P-value	Spearman’s r
Lipids associated with the PLA₂ pathway
Pentadecanoate (15:0)	0.03	0.39
1-Eicosatrienoylglycerophosphoethanolamine*	0.04	0.38
Arachidonate (20:4n6)	0.04	0.38
1-Oleoylglycerophosphoethanolamine	0.05	0.37
Other lipids
Butyrylcarnitine	0.01	0.46
2-Linoleoylglycerol (2-monolinolein)	0.02	0.42
Octanoylcarnitine	0.03	0.41
5-Hydroxyhexanoate	0.04	0.37
Other metabolites
Phenylacetate	0.00	0.52
1,3,7-trimethylurate	0.00	0.52
Alpha-ketoglutarate	0.01	0.46
Mannitol	0.01	0.45
3-hydroxy-2-ethylpropionate	0.02	0.43
Paraxanthine	0.02	0.42
Thymol sulfate	0.04	0.38
l-urobilin	0.04	0.37
Sucrose	0.04	0.37

Analysis carried out on from 30 samples collected in 2011 and 2013 are shown (p-value <0.05). Asterisk represents a metabolite that was identified based on its chromatographic and mass spectra rather than a purified standard

ISSN: 1475-2875